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1fzv

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[[Image:1fzv.gif|left|200px]]
[[Image:1fzv.gif|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1fzv", creates the "Structure Box" on the page.
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{{STRUCTURE_1fzv| PDB=1fzv | SCENE= }}
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|RELATEDENTRY=[[2vpf|2VPF]], [[1flt|1FLT]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fzv OCA], [http://www.ebi.ac.uk/pdbsum/1fzv PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1fzv RCSB]</span>
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'''THE CRYSTAL STRUCTURE OF HUMAN PLACENTA GROWTH FACTOR-1 (PLGF-1), AN ANGIOGENIC PROTEIN AT 2.0A RESOLUTION'''
'''THE CRYSTAL STRUCTURE OF HUMAN PLACENTA GROWTH FACTOR-1 (PLGF-1), AN ANGIOGENIC PROTEIN AT 2.0A RESOLUTION'''
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[[Category: Swaminathan, G J.]]
[[Category: Swaminathan, G J.]]
[[Category: Tucci, M.]]
[[Category: Tucci, M.]]
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[[Category: angiogenesis]]
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[[Category: Angiogenesis]]
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[[Category: cysteine-knot family]]
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[[Category: Cysteine-knot family]]
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[[Category: growth factor]]
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[[Category: Growth factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:57:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:33:36 2008''
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Revision as of 13:57, 2 May 2008

Image:1fzv.gif

Template:STRUCTURE 1fzv

THE CRYSTAL STRUCTURE OF HUMAN PLACENTA GROWTH FACTOR-1 (PLGF-1), AN ANGIOGENIC PROTEIN AT 2.0A RESOLUTION


Overview

The angiogenic molecule placenta growth factor (PlGF) is a member of the cysteine-knot family of growth factors. In this study, a mature isoform of the human PlGF protein, PlGF-1, was crystallized as a homodimer in the crystallographic asymmetric unit, and its crystal structure was elucidated at 2.0 A resolution. The overall structure of PlGF-1 is similar to that of vascular endothelial growth factor (VEGF) with which it shares 42% amino acid sequence identity. Based on structural and biochemical data, we have mapped several important residues on the PlGF-1 molecule that are involved in recognition of the fms-like tyrosine kinase receptor (Flt-1, also known as VEGFR-1). We propose a model for the association of PlGF-1 and Flt-1 domain 2 with precise shape complementarity, consider the relevance of this assembly for PlGF-1 signal transduction, and provide a structural basis for altered specificity of this molecule.

About this Structure

1FZV is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The crystal structure of human placenta growth factor-1 (PlGF-1), an angiogenic protein, at 2.0 A resolution., Iyer S, Leonidas DD, Swaminathan GJ, Maglione D, Battisti M, Tucci M, Persico MG, Acharya KR, J Biol Chem. 2001 Apr 13;276(15):12153-61. Epub 2000 Nov 7. PMID:11069911 Page seeded by OCA on Fri May 2 16:57:13 2008

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