Inhibitory neurosteroids
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
<StructureSection load='5osb' size='340' side='right' caption=''> | <StructureSection load='5osb' size='340' side='right' caption=''> | ||
| - | These neurosteroids exert inhibitory actions on neurotransmission. They act as positive allosteric modulators of the [[GABAA receptor]] (especially δ subunit-containing isoforms), and possess, in no particular order, antidepressant, anxiolytic, stress-reducing, rewarding, prosocial, antiaggressive, prosexual, sedative, pro-sleep, cognitive and memory-impairing, analgesic, anesthetic, anticonvulsant, neuroprotective, and neurogenic effects. | + | These [[neurosteroids]] exert inhibitory actions on neurotransmission. They act as positive allosteric modulators of the [[GABAA receptor]] (especially δ subunit-containing isoforms), and possess, in no particular order, antidepressant, anxiolytic, stress-reducing, rewarding, prosocial, antiaggressive, prosexual, sedative, pro-sleep, cognitive and memory-impairing, analgesic, anesthetic, anticonvulsant, neuroprotective, and neurogenic effects. |
Major examples include <scene name='89/896619/Cv/7'>tetrahydrodeoxycorticosterone</scene> (THDOC; from [[5osb]]), the androstane 3α-androstanediol, the cholestane cholesterol and the pregnanes pregnanolone (eltanolone), allopregnanolone (3α,5α-THP). | Major examples include <scene name='89/896619/Cv/7'>tetrahydrodeoxycorticosterone</scene> (THDOC; from [[5osb]]), the androstane 3α-androstanediol, the cholestane cholesterol and the pregnanes pregnanolone (eltanolone), allopregnanolone (3α,5α-THP). | ||
Revision as of 13:17, 26 December 2021
| |||||||||||
