1d4x

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(New page: 200px<br /> <applet load="1d4x" size="450" color="white" frame="true" align="right" spinBox="true" caption="1d4x, resolution 1.75&Aring;" /> '''Crystal Structure o...)
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Revision as of 14:22, 12 November 2007

Image:1d4x.gif

1d4x, resolution 1.75Å

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Crystal Structure of Caenorhabditis Elegans Mg-ATP Actin Complexed with Human Gelsolin Segment 1 at 1.75 A resolution.

Contents

Overview

The structures of Saccharomyces cerevisiae, Dictyostelium, and, Caenorhabditis elegans actin bound to gelsolin segment-1 have been solved, and refined at resolutions between 1.9 and 1.75 A. These structures reveal, several features relevant to the ATP hydrolytic mechanism, including, identification of the nucleophilic water and the roles of Gln-137 and, His-161 in positioning and activating the catalytic water, respectively., The involvement of these residues in the catalytic mechanism is consistent, with yeast genetics studies. This work highlights both structural and, mechanistic similarities with the small and trimeric G proteins and, restricts the types of mechanisms responsible for the considerable, enhancement of ATP hydrolysis associated with actin polymerization. The, conservation of functionalities involved in nucleotide binding and, catalysis also provide insights into the mechanistic features of members, of the family of actin-related proteins.

Disease

Known disease associated with this structure: Amyloidosis, Finnish type OMIM:[137350]

About this Structure

1D4X is a Protein complex structure of sequences from Caenorhabditis elegans and Homo sapiens with MG, CA, SO4, ATP and SO2 as ligands. Full crystallographic information is available from OCA.

Reference

The structure of nonvertebrate actin: implications for the ATP hydrolytic mechanism., Vorobiev S, Strokopytov B, Drubin DG, Frieden C, Ono S, Condeelis J, Rubenstein PA, Almo SC, Proc Natl Acad Sci U S A. 2003 May 13;100(10):5760-5. Epub 2003 May 5. PMID:12732734

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