1d5g
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(New page: 200px<br /> <applet load="1d5g" size="450" color="white" frame="true" align="right" spinBox="true" caption="1d5g" /> '''SOLUTION STRUCTURE OF THE PDZ2 DOMAIN FROM ...)
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Revision as of 14:22, 12 November 2007
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SOLUTION STRUCTURE OF THE PDZ2 DOMAIN FROM HUMAN PHOSPHATASE HPTP1E COMPLEXED WITH A PEPTIDE
Overview
The solution structure of the second PDZ domain from human phosphatase, hPTP1E in complex with a C-terminal peptide from the guanine nucleotide, exchange factor RA-GEF-2 has been determined using 2D and 3D heteronuclear, NMR experiments. Compared to previously solved structures, the hPTP1E, complex shows an enlarged interaction surface with the C terminus of the, bound peptide. Novel contacts were found between the long structured, beta2/beta3 loop of the PDZ domain and the sixth amino acid residue from, the C terminus of the peptide. This work underlines the importance of the, beta2/beta3 loop for ligand selection by PDZ domains.
About this Structure
1D5G is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Solution structure of the PDZ2 domain from cytosolic human phosphatase hPTP1E complexed with a peptide reveals contribution of the beta2-beta3 loop to PDZ domain-ligand interactions., Kozlov G, Banville D, Gehring K, Ekiel I, J Mol Biol. 2002 Jul 19;320(4):813-20. PMID:12095257
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