7d8f
From Proteopedia
(Difference between revisions)
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==The crystal structure of ScNTM1 in complex with SAH== | ==The crystal structure of ScNTM1 in complex with SAH== | ||
| - | <StructureSection load='7d8f' size='340' side='right'caption='[[7d8f]]' scene=''> | + | <StructureSection load='7d8f' size='340' side='right'caption='[[7d8f]], [[Resolution|resolution]] 1.15Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7D8F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7D8F FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7d8f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7D8F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7D8F FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7d8f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7d8f OCA], [https://pdbe.org/7d8f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7d8f RCSB], [https://www.ebi.ac.uk/pdbsum/7d8f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7d8f ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr> |
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TAE1, NTM1, YBR261C, YBR1729 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Protein_N-terminal_methyltransferase Protein N-terminal methyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.244 2.1.1.244] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7d8f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7d8f OCA], [https://pdbe.org/7d8f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7d8f RCSB], [https://www.ebi.ac.uk/pdbsum/7d8f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7d8f ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/NTM1_YEAST NTM1_YEAST]] Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Responsible for the N-terminal methylation of the ribosomal proteins RPL12A, RPL12B, RPS25A and RPS25B.<ref>PMID:20481588</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Atcc 18824]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Yue J]] | + | [[Category: Protein N-terminal methyltransferase]] |
| - | [[Category: Zhang | + | [[Category: Yue, J]] |
| - | [[Category: Zhu | + | [[Category: Zhang, H Y]] |
| + | [[Category: Zhu, Z L]] | ||
| + | [[Category: Methyltransferase]] | ||
| + | [[Category: N-terminal methylation]] | ||
| + | [[Category: Saccharomyces cerevisiae]] | ||
| + | [[Category: Scntm1]] | ||
| + | [[Category: Substrate binding pocket]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 14:15, 29 December 2021
The crystal structure of ScNTM1 in complex with SAH
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