7lgc
From Proteopedia
(Difference between revisions)
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==MOAP1 CA-like C-terminal domain== | ==MOAP1 CA-like C-terminal domain== | ||
| - | <StructureSection load='7lgc' size='340' side='right'caption='[[7lgc]]' scene=''> | + | <StructureSection load='7lgc' size='340' side='right'caption='[[7lgc]], [[Resolution|resolution]] 1.85Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LGC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LGC FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7lgc]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LGC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LGC FirstGlance]. <br> |
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lgc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lgc OCA], [https://pdbe.org/7lgc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lgc RCSB], [https://www.ebi.ac.uk/pdbsum/7lgc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lgc ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lgc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lgc OCA], [https://pdbe.org/7lgc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lgc RCSB], [https://www.ebi.ac.uk/pdbsum/7lgc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lgc ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/MOAP1_HUMAN MOAP1_HUMAN]] Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation.<ref>PMID:15949439</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The Gag proteins of retroviruses play an essential role in virus particle assembly by forming a protein shell or capsid and thus generating the virion compartment. A variety of human proteins have now been identified with structural similarity to one or more of the major Gag domains. These human proteins are thought to have been evolved or "domesticated" from ancient integrations due to retroviral infections or retrotransposons. Here, we report that X-ray crystal structures of stably folded domains of MOAP1 (modulator of apoptosis 1) and PEG10 (paternally expressed gene 10) are highly similar to the C-terminal capsid (CA) domains of cognate Gag proteins. The structures confirm classification of MOAP1 and PEG10 as domesticated Gags, and suggest that these proteins may have preserved some of the key interactions that facilitated assembly of their ancestral Gags into capsids. | ||
| + | |||
| + | Structural evidence that MOAP1 and PEG10 are derived from retrovirus/retrotransposon Gag proteins.,Zurowska K, Alam A, Ganser-Pornillos BK, Pornillos O Proteins. 2021 Aug 6. doi: 10.1002/prot.26204. PMID:34357660<ref>PMID:34357660</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7lgc" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Ganser-Pornillos | + | [[Category: Ganser-Pornillos, B K]] |
| - | [[Category: Pornillos O]] | + | [[Category: Pornillos, O]] |
| - | [[Category: Zurowska K]] | + | [[Category: Zurowska, K]] |
| + | [[Category: Apoptosis]] | ||
| + | [[Category: Domesticated gag]] | ||
Revision as of 14:16, 29 December 2021
MOAP1 CA-like C-terminal domain
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