2gyt

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<StructureSection load='2gyt' size='340' side='right'caption='[[2gyt]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
<StructureSection load='2gyt' size='340' side='right'caption='[[2gyt]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2gyt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GYT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GYT FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2gyt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GYT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GYT FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gyt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gyt OCA], [http://pdbe.org/2gyt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2gyt RCSB], [http://www.ebi.ac.uk/pdbsum/2gyt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2gyt ProSAT]</span></td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gyt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gyt OCA], [https://pdbe.org/2gyt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gyt RCSB], [https://www.ebi.ac.uk/pdbsum/2gyt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gyt ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/RHG07_HUMAN RHG07_HUMAN]] Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality.<ref>PMID:18786931</ref> <ref>PMID:19170769</ref> <ref>PMID:19710422</ref>
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[[https://www.uniprot.org/uniprot/RHG07_HUMAN RHG07_HUMAN]] Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality.<ref>PMID:18786931</ref> <ref>PMID:19170769</ref> <ref>PMID:19710422</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]

Revision as of 11:03, 5 January 2022

Solution structure of the SAM (sterile alpha motif) domain of DLC1 (deleted in liver cancer 1)

PDB ID 2gyt

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