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3b93
From Proteopedia
(Difference between revisions)
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==crystal structure of human GITRL== | ==crystal structure of human GITRL== | ||
| - | <StructureSection load='3b93' size='340' side='right' caption='[[3b93]], [[Resolution|resolution]] 2.20Å' scene=''> | + | <StructureSection load='3b93' size='340' side='right'caption='[[3b93]], [[Resolution|resolution]] 2.20Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3b93]] is a 3 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3b93]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B93 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3B93 FirstGlance]. <br> |
| - | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3b94|3b94]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3b94|3b94]]</div></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TNFSF18, AITRL, GITRL, TL6 ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TNFSF18, AITRL, GITRL, TL6 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3b93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b93 OCA], [https://pdbe.org/3b93 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3b93 RCSB], [https://www.ebi.ac.uk/pdbsum/3b93 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3b93 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/TNF18_HUMAN TNF18_HUMAN]] Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B.<ref>PMID:17449724</ref> <ref>PMID:18040044</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
| - | *[[Tumor necrosis factor ligand superfamily|Tumor necrosis factor ligand superfamily]] | + | *[[Tumor necrosis factor ligand superfamily 3D structures|Tumor necrosis factor ligand superfamily 3D structures]] |
| - | *[[Tumor necrosis factor receptor|Tumor necrosis factor receptor]] | + | *[[Tumor necrosis factor receptor 3D structures|Tumor necrosis factor receptor 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Song, X M]] | [[Category: Song, X M]] | ||
[[Category: Zhou, Z C]] | [[Category: Zhou, Z C]] | ||
Current revision
crystal structure of human GITRL
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Categories: Human | Large Structures | Song, X M | Zhou, Z C | Asymmetric | C2 spacegroup | Cytokine | Glycoprotein | Membrane | Open trimer | Signal-anchor | Transmembrane
