This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1g3j

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1g3j.gif|left|200px]]
[[Image:1g3j.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1g3j |SIZE=350|CAPTION= <scene name='initialview01'>1g3j</scene>, resolution 2.1&Aring;
+
The line below this paragraph, containing "STRUCTURE_1g3j", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND=
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1g3j| PDB=1g3j | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1g3j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g3j OCA], [http://www.ebi.ac.uk/pdbsum/1g3j PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1g3j RCSB]</span>
+
-
}}
+
'''CRYSTAL STRUCTURE OF THE XTCF3-CBD/BETA-CATENIN ARMADILLO REPEAT COMPLEX'''
'''CRYSTAL STRUCTURE OF THE XTCF3-CBD/BETA-CATENIN ARMADILLO REPEAT COMPLEX'''
Line 31: Line 28:
[[Category: Weaver, C.]]
[[Category: Weaver, C.]]
[[Category: Xu, W.]]
[[Category: Xu, W.]]
-
[[Category: beta-catenin,tcf-3]]
+
[[Category: Beta-catenin,tcf-3]]
-
[[Category: protein-protein complex]]
+
[[Category: Protein-protein complex]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:05:31 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:35:48 2008''
+

Revision as of 14:05, 2 May 2008

Image:1g3j.gif

Template:STRUCTURE 1g3j

CRYSTAL STRUCTURE OF THE XTCF3-CBD/BETA-CATENIN ARMADILLO REPEAT COMPLEX


Overview

The Wnt signaling pathway plays critical roles in embryonic development and tumorigenesis. Stimulation of the Wnt pathway results in the accumulation of a nuclear beta-catenin/Tcf complex, activating Wnt target genes. A crystal structure of beta-catenin bound to the beta-catenin binding domain of Tcf3 (Tcf3-CBD) has been determined. The Tcf3-CBD forms an elongated structure with three binding modules that runs antiparallel to beta-catenin along the positively charged groove formed by the armadillo repeats. Structure-based mutagenesis defines three sites in beta-catenin that are critical for binding the Tcf3-CBD and are differentially involved in binding APC, cadherin, and Axin. The structural and mutagenesis data reveal a potential target for molecular drug design studies.

About this Structure

1G3J is a Protein complex structure of sequences from Homo sapiens and Xenopus laevis. Full crystallographic information is available from OCA.

Reference

Crystal structure of a beta-catenin/Tcf complex., Graham TA, Weaver C, Mao F, Kimelman D, Xu W, Cell. 2000 Dec 8;103(6):885-96. PMID:11136974 Page seeded by OCA on Fri May 2 17:05:31 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1g3j"
Personal tools