1g3x
From Proteopedia
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'''INTERCALATION OF AN 9ACRIDINE-PEPTIDE DRUG IN A DNA DODECAMER''' | '''INTERCALATION OF AN 9ACRIDINE-PEPTIDE DRUG IN A DNA DODECAMER''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | + | Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G3X OCA]. | |
==Reference== | ==Reference== | ||
Intercalation of an acridine-peptide drug in an AA/TT base step in the crystal structure of [d(CGCGAATTCGCG)](2) with six duplexes and seven Mg(2+) ions in the asymmetric unit., Malinina L, Soler-Lopez M, Aymami J, Subirana JA, Biochemistry. 2002 Jul 30;41(30):9341-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12135355 12135355] | Intercalation of an acridine-peptide drug in an AA/TT base step in the crystal structure of [d(CGCGAATTCGCG)](2) with six duplexes and seven Mg(2+) ions in the asymmetric unit., Malinina L, Soler-Lopez M, Aymami J, Subirana JA, Biochemistry. 2002 Jul 30;41(30):9341-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12135355 12135355] | ||
| - | [[Category: Protein complex]] | ||
[[Category: Aymami, J.]] | [[Category: Aymami, J.]] | ||
[[Category: Malinina, L.]] | [[Category: Malinina, L.]] | ||
[[Category: Soler-Lopez, M.]] | [[Category: Soler-Lopez, M.]] | ||
[[Category: Subirana, J A.]] | [[Category: Subirana, J A.]] | ||
| - | [[Category: | + | [[Category: Dna]] |
| - | [[Category: | + | [[Category: Drug-peptide adduct]] |
| - | [[Category: | + | [[Category: Intercalation]] |
| - | [[Category: | + | [[Category: Mg+2 ion]] |
| - | [[Category: | + | [[Category: X-ray structure]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:06:23 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 14:06, 2 May 2008
INTERCALATION OF AN 9ACRIDINE-PEPTIDE DRUG IN A DNA DODECAMER
Overview
We present the crystal structure of an acridine drug derivatized at carbon 9, [N(alpha)-(9-acridinoyl)-tetraarginine], intercalated within the dodecamer [d(CGCGAATTCGCG)](2). The presence of a lateral chain at the central carbon 9 atom differentiates this compound from most acridine drugs hitherto studied, which are usually derivatized at carbon 4. The DNA:drug interaction we observe differs from that observed in previous studies, which primarily involves shorter, mainly hexameric sequences, in two important regards: the acridine intercalates within an AA/TT base step, rather than within a CG/CG base step; and the binding site is located at the center of the sequence, rather than at one end of the duplex. In addition, we observe a novel crystal packing arrangement, with six dodecamer duplexes and seven hydrated magnesium ions in the asymmetric unit of a large (66.5 x 68.4 x 77.4 A(3)) unit cell in space group P2(1)2(1)2(1). The duplexes are organized in layers parallel to the ab plane, with consecutive layers crossing each other at right angles.
About this Structure
Full crystallographic information is available from OCA.
Reference
Intercalation of an acridine-peptide drug in an AA/TT base step in the crystal structure of [d(CGCGAATTCGCG)](2) with six duplexes and seven Mg(2+) ions in the asymmetric unit., Malinina L, Soler-Lopez M, Aymami J, Subirana JA, Biochemistry. 2002 Jul 30;41(30):9341-8. PMID:12135355 Page seeded by OCA on Fri May 2 17:06:23 2008
