7t4x
From Proteopedia
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==AKT1 K+ channel from A. thaliana in MSP2N2 lipid nanodisc== | ==AKT1 K+ channel from A. thaliana in MSP2N2 lipid nanodisc== | ||
| - | <StructureSection load='7t4x' size='340' side='right'caption='[[7t4x]]' scene=''> | + | <StructureSection load='7t4x' size='340' side='right'caption='[[7t4x]], [[Resolution|resolution]] 2.80Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T4X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T4X FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7t4x]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T4X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T4X FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t4x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t4x OCA], [https://pdbe.org/7t4x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t4x RCSB], [https://www.ebi.ac.uk/pdbsum/7t4x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t4x ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PTY:PHOSPHATIDYLETHANOLAMINE'>PTY</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t4x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t4x OCA], [https://pdbe.org/7t4x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t4x RCSB], [https://www.ebi.ac.uk/pdbsum/7t4x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t4x ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/AKT1_ARATH AKT1_ARATH]] Highly selective inward-rectifying potassium channel that mediate potassium uptake by plant roots in response to low K(+) conditions, by a calcium-, CBL-, and CIPK-dependent pathway. Positively regulated by phosphorylation by CIPK23. Negatively regulated by a kinase-independent regulatory mechanism involving a competing direct binding of CBL10. Involved in the stomatal regulation by monitoring the turgor pressure in guard cells. Assuming opened or closed conformations in response to the voltage difference across the membrane, the channel is activated by hyperpolarization. May interact with the cytoskeleton or with regulatory proteins.<ref>PMID:12678562</ref> <ref>PMID:16814720</ref> <ref>PMID:16895985</ref> <ref>PMID:17898163</ref> <ref>PMID:9572739</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Plants obtain nutrients from the soil via transmembrane transporters and channels in their root hairs, from which ions radially transport in toward the xylem for distribution across the plant body. We determined structures of the hyperpolarization-activated channel AKT1 from Arabidopsis thaliana, which mediates K(+) uptake from the soil into plant roots. These structures of AtAKT1 embedded in lipid nanodiscs show that the channel undergoes a reduction of C4 to C2 symmetry, possibly to regulate its electrical activation. | ||
| + | |||
| + | Symmetry Reduction in a Hyperpolarization-Activated Homotetrameric Ion Channel.,Dickinson MS, Pourmal S, Gupta M, Bi M, Stroud RM Biochemistry. 2021 Dec 29. doi: 10.1021/acs.biochem.1c00654. PMID:34964607<ref>PMID:34964607</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7t4x" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Dickinson | + | [[Category: Dickinson, M S]] |
| - | [[Category: Pourmal S]] | + | [[Category: Pourmal, S]] |
| + | [[Category: Hyperpolarization-activated channel]] | ||
| + | [[Category: Ion channel]] | ||
| + | [[Category: K+ channel]] | ||
| + | [[Category: Membrane protein]] | ||
| + | [[Category: Voltage-gated channel]] | ||
Revision as of 10:05, 12 January 2022
AKT1 K+ channel from A. thaliana in MSP2N2 lipid nanodisc
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