1g43
From Proteopedia
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'''CRYSTAL STRUCTURE OF A FAMILY IIIA CBD FROM CLOSTRIDIUM CELLULOLYTICUM''' | '''CRYSTAL STRUCTURE OF A FAMILY IIIA CBD FROM CLOSTRIDIUM CELLULOLYTICUM''' | ||
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[[Category: Shimon, L J.W.]] | [[Category: Shimon, L J.W.]] | ||
[[Category: Shoham, Y.]] | [[Category: Shoham, Y.]] | ||
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Revision as of 14:06, 2 May 2008
CRYSTAL STRUCTURE OF A FAMILY IIIA CBD FROM CLOSTRIDIUM CELLULOLYTICUM
Overview
The crystal structure of the family IIIa cellulose-binding domain (CBD) from the cellulosomal scaffoldin subunit (CipC) of Clostridium cellulolyticum has been determined. The structure reveals a nine-stranded jelly-roll topology which exhibits distinctive structural elements consistent with family III CBDs that bind crystalline cellulose. These include a well conserved calcium-binding site, a putative cellulose-binding surface and a conserved shallow groove of unknown function. The CipC CBD structure is very similar to the previously elucidated family IIIa CBD from the CipA scaffoldin of C. thermocellum, with some minor differences. The CipC CBD structure was also compared with other previously described CBD structures from families IIIc and IV derived from the endoglucanases of Thermomonospora fusca and Cellulomonas fimi, respectively. The possible functional consequences of structural similarities and differences in the shallow groove and cellulose-binding faces among various CBD families and subfamilies are discussed.
About this Structure
1G43 is a Single protein structure of sequence from Clostridium cellulolyticum. Full crystallographic information is available from OCA.
Reference
Structure of a family IIIa scaffoldin CBD from the cellulosome of Clostridium cellulolyticum at 2.2 A resolution., Shimon LJ, Pages S, Belaich A, Belaich JP, Bayer EA, Lamed R, Shoham Y, Frolow F, Acta Crystallogr D Biol Crystallogr. 2000 Dec;56(Pt 12):1560-8. PMID:11092922 Page seeded by OCA on Fri May 2 17:06:46 2008
