1g4d

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[[Image:1g4d.gif|left|200px]]
[[Image:1g4d.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1g4d |SIZE=350|CAPTION= <scene name='initialview01'>1g4d</scene>
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The line below this paragraph, containing "STRUCTURE_1g4d", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= MU C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10677 Enterobacteria phage Mu])
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-->
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|DOMAIN=
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{{STRUCTURE_1g4d| PDB=1g4d | SCENE= }}
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|RELATEDENTRY=[[1qpm|1QPM]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1g4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g4d OCA], [http://www.ebi.ac.uk/pdbsum/1g4d PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1g4d RCSB]</span>
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}}
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'''NMR STRUCTURE OF THE MU BACTERIOPHAGE REPRESSOR DNA-BINDING DOMAIN/DNA COMPLEX'''
'''NMR STRUCTURE OF THE MU BACTERIOPHAGE REPRESSOR DNA-BINDING DOMAIN/DNA COMPLEX'''
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[[Category: Iwahara, J.]]
[[Category: Iwahara, J.]]
[[Category: Wojciak, J M.]]
[[Category: Wojciak, J M.]]
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[[Category: bacteriophage mu]]
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[[Category: Bacteriophage mu]]
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[[Category: helix-turn-helix]]
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[[Category: Helix-turn-helix]]
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[[Category: protein/dna complex]]
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[[Category: Protein/dna complex]]
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[[Category: repressor]]
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[[Category: Repressor]]
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[[Category: virus/viral protein]]
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[[Category: Virus/viral protein]]
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[[Category: winged-helix]]
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[[Category: Winged-helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:07:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:36:21 2008''
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Revision as of 14:07, 2 May 2008

Image:1g4d.gif

Template:STRUCTURE 1g4d

NMR STRUCTURE OF THE MU BACTERIOPHAGE REPRESSOR DNA-BINDING DOMAIN/DNA COMPLEX


Overview

We have determined the solution structure of the complex between the 'winged-helix' enhancer binding domain of the Mu repressor protein and its cognate DNA site. The structure reveals an unusual use for the 'wing' which becomes immobilized upon DNA binding where it makes intermolecular hydrogen bond contacts deep within the minor groove. Although the wing is mobile in the absence of DNA, it partially negates the large entropic penalty associated with its burial by maintaining a small degree of structural order in the DNA-free state. Extensive contacts are also formed between the recognition helix and the DNA, which reads the major groove of a highly conserved region of the binding site through a single base-specific hydrogen bond and van der Waals contacts.

About this Structure

1G4D is a Single protein structure of sequence from Enterobacteria phage mu. Full crystallographic information is available from OCA.

Reference

The Mu repressor-DNA complex contains an immobilized 'wing' within the minor groove., Wojciak JM, Iwahara J, Clubb RT, Nat Struct Biol. 2001 Jan;8(1):84-90. PMID:11135677 Page seeded by OCA on Fri May 2 17:07:27 2008

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