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3blw
From Proteopedia
(Difference between revisions)
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==Yeast Isocitrate Dehydrogenase with Citrate and AMP Bound in the Regulatory Subunits== | ==Yeast Isocitrate Dehydrogenase with Citrate and AMP Bound in the Regulatory Subunits== | ||
| - | <StructureSection load='3blw' size='340' side='right' caption='[[3blw]], [[Resolution|resolution]] 4.30Å' scene=''> | + | <StructureSection load='3blw' size='340' side='right'caption='[[3blw]], [[Resolution|resolution]] 4.30Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3blw]] is a 16 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3blw]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. The September 2010 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Isocitrate Dehydrogenase'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2010_9 10.2210/rcsb_pdb/mom_2010_9]. The October 2012 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Citric Acid Cycle'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2012_10 10.2210/rcsb_pdb/mom_2012_10]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BLW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BLW FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene></td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3blx|3blx]], [[3blv|3blv]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3blx|3blx]], [[3blv|3blv]]</div></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IDH1 ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IDH1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824]), IDH2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr> |
| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Isocitrate_dehydrogenase_(NAD(+)) Isocitrate dehydrogenase (NAD(+))], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.41 1.1.1.41] </span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3blw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3blw OCA], [https://pdbe.org/3blw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3blw RCSB], [https://www.ebi.ac.uk/pdbsum/3blw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3blw ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/IDH1_YEAST IDH1_YEAST]] Performs an essential role in the oxidative function of the citric acid cycle. Also binds RNA; specifically to the 5'-untranslated leaders of mitochondrial mRNAs. [[https://www.uniprot.org/uniprot/IDH2_YEAST IDH2_YEAST]] Performs an essential role in the oxidative function of the citric acid cycle. Also binds RNA; specifically to the 5'-untranslated leaders of mitochondrial mRNAs. |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
| - | *[[Isocitrate dehydrogenase|Isocitrate dehydrogenase]] | + | *[[Isocitrate dehydrogenase 3D structures|Isocitrate dehydrogenase 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
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[[Category: Citric Acid Cycle]] | [[Category: Citric Acid Cycle]] | ||
[[Category: Isocitrate Dehydrogenase]] | [[Category: Isocitrate Dehydrogenase]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: RCSB PDB Molecule of the Month]] | [[Category: RCSB PDB Molecule of the Month]] | ||
[[Category: Hart, P J]] | [[Category: Hart, P J]] | ||
Revision as of 10:46, 12 January 2022
Yeast Isocitrate Dehydrogenase with Citrate and AMP Bound in the Regulatory Subunits
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Categories: Atcc 18824 | Citric Acid Cycle | Isocitrate Dehydrogenase | Large Structures | RCSB PDB Molecule of the Month | Hart, P J | Hu, G | McAlister-Henn, L | Taylor, A B | Allosteric enzyme | Allostery | Decarboxylase | Dehydrogenase | Magnesium | Manganese | Metal-binding | Mitochondrion | Nad | Oxidative metabolism | Oxidoreductase | Phosphoprotein | Rna-binding | Tca cycle | Transit peptide | Tricarboxylic acid cycle
