1de4
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(New page: 200px<br /> <applet load="1de4" size="450" color="white" frame="true" align="right" spinBox="true" caption="1de4, resolution 2.80Å" /> '''HEMOCHROMATOSIS PRO...)
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Revision as of 14:24, 12 November 2007
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HEMOCHROMATOSIS PROTEIN HFE COMPLEXED WITH TRANSFERRIN RECEPTOR
Contents |
Overview
HFE is related to major histocompatibility complex (MHC) class I proteins, and is mutated in the iron-overload disease hereditary haemochromatosis., HFE binds to the transferrin receptor (TfR), a receptor by which cells, acquire iron-loaded transferrin. The 2.8 A crystal structure of a complex, between the extracellular portions of HFE and TfR shows two HFE molecules, which grasp each side of a twofold symmetric TfR dimer. On a cell membrane, containing both proteins, HFE would 'lie down' parallel to the membrane, such that the HFE helices that delineate the counterpart of the MHC, peptide-binding groove make extensive contacts with helices in the TfR, dimerization domain. The structures of TfR alone and complexed with HFE, differ in their domain arrangement and dimer interfaces, providing a, mechanism for communicating binding events between TfR chains. The HFE-TfR, complex suggests a binding site for transferrin on TfR and sheds light, upon the function of HFE in regulating iron homeostasis.
Disease
Known diseases associated with this structure: Hemochromatosis OMIM:[235200], Hypoproteinemia, hypercatabolic OMIM:[109700], Porphyria variegata OMIM:[235200]
About this Structure
1DE4 is a Protein complex structure of sequences from Homo sapiens with NAG, CA and GOL as ligands. Full crystallographic information is available from OCA.
Reference
Crystal structure of the hereditary haemochromatosis protein HFE complexed with transferrin receptor., Bennett MJ, Lebron JA, Bjorkman PJ, Nature. 2000 Jan 6;403(6765):46-53. PMID:10638746
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