2iyc

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<StructureSection load='2iyc' size='340' side='right'caption='[[2iyc]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
<StructureSection load='2iyc' size='340' side='right'caption='[[2iyc]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2iyc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IYC OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2IYC FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2iyc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IYC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IYC FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2ckg|2ckg]], [[2ckh|2ckh]], [[2iy0|2iy0]], [[2iy1|2iy1]], [[2iyd|2iyd]]</td></tr>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2ckg|2ckg]], [[2ckh|2ckh]], [[2iy0|2iy0]], [[2iy1|2iy1]], [[2iyd|2iyd]]</div></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2iyc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iyc OCA], [http://pdbe.org/2iyc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2iyc RCSB], [http://www.ebi.ac.uk/pdbsum/2iyc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2iyc ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2iyc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iyc OCA], [https://pdbe.org/2iyc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2iyc RCSB], [https://www.ebi.ac.uk/pdbsum/2iyc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2iyc ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SENP1_HUMAN SENP1_HUMAN]] Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1, which decreases its transcriptional repression activity.<ref>PMID:10652325</ref> <ref>PMID:15199155</ref> <ref>PMID:16253240</ref> <ref>PMID:16553580</ref>
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[[https://www.uniprot.org/uniprot/SENP1_HUMAN SENP1_HUMAN]] Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1, which decreases its transcriptional repression activity.<ref>PMID:10652325</ref> <ref>PMID:15199155</ref> <ref>PMID:16253240</ref> <ref>PMID:16553580</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]

Revision as of 07:56, 19 January 2022

SENP1 native structure

PDB ID 2iyc

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