This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2jk5

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 3: Line 3:
<StructureSection load='2jk5' size='340' side='right'caption='[[2jk5]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='2jk5' size='340' side='right'caption='[[2jk5]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[2jk5]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/"actinomyces_lividans"_krasil'nikov_et_al._1965 "actinomyces lividans" krasil'nikov et al. 1965] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JK5 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2JK5 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[2jk5]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/"actinomyces_lividans"_krasil'nikov_et_al._1965 "actinomyces lividans" krasil'nikov et al. 1965] and [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JK5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JK5 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=F09:NONAN-1-OL'>F09</scene>, <scene name='pdbligand=HP6:HEPTANE'>HP6</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=L2C:(2S)-3-HYDROXY-2-(NONANOYLOXY)PROPYL+LAURATE'>L2C</scene>, <scene name='pdbligand=TBA:TETRABUTYLAMMONIUM+ION'>TBA</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=F09:NONAN-1-OL'>F09</scene>, <scene name='pdbligand=HP6:HEPTANE'>HP6</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=L2C:(2S)-3-HYDROXY-2-(NONANOYLOXY)PROPYL+LAURATE'>L2C</scene>, <scene name='pdbligand=TBA:TETRABUTYLAMMONIUM+ION'>TBA</scene></td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1r3k|1r3k]], [[2a9h|2a9h]], [[1k4d|1k4d]], [[1k4c|1k4c]], [[2hg5|2hg5]], [[2bob|2bob]], [[1f6g|1f6g]], [[2boc|2boc]], [[1jq2|1jq2]], [[1r3j|1r3j]], [[1jvm|1jvm]], [[1jq1|1jq1]], [[2ih3|2ih3]], [[1zwi|1zwi]], [[1bl8|1bl8]], [[1r3i|1r3i]], [[2w0f|2w0f]], [[2ih1|2ih1]], [[1j95|1j95]], [[2h8p|2h8p]], [[1r3l|1r3l]], [[2atk|2atk]], [[4uuj|4uuj]]</td></tr>
+
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1r3k|1r3k]], [[2a9h|2a9h]], [[1k4d|1k4d]], [[1k4c|1k4c]], [[2hg5|2hg5]], [[2bob|2bob]], [[1f6g|1f6g]], [[2boc|2boc]], [[1jq2|1jq2]], [[1r3j|1r3j]], [[1jvm|1jvm]], [[1jq1|1jq1]], [[2ih3|2ih3]], [[1zwi|1zwi]], [[1bl8|1bl8]], [[1r3i|1r3i]], [[2w0f|2w0f]], [[2ih1|2ih1]], [[1j95|1j95]], [[2h8p|2h8p]], [[1r3l|1r3l]], [[2atk|2atk]], [[4uuj|4uuj]]</div></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2jk5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jk5 OCA], [http://pdbe.org/2jk5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2jk5 RCSB], [http://www.ebi.ac.uk/pdbsum/2jk5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2jk5 ProSAT]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jk5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jk5 OCA], [https://pdbe.org/2jk5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jk5 RCSB], [https://www.ebi.ac.uk/pdbsum/2jk5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jk5 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/KCSA_STRLI KCSA_STRLI]] Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel, although it is not clear if this is the physiological stimulus for channel opening. Monovalent cation preference is K(+) > Rb(+) > NH4(+) >> Na(+) > Li(+).<ref>PMID:7489706</ref>
+
[[https://www.uniprot.org/uniprot/KCSA_STRLI KCSA_STRLI]] Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel, although it is not clear if this is the physiological stimulus for channel opening. Monovalent cation preference is K(+) > Rb(+) > NH4(+) >> Na(+) > Li(+).<ref>PMID:7489706</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]

Revision as of 08:13, 19 January 2022

Potassium Channel KcsA in complex with Tetrabutylammonium in high K

PDB ID 2jk5

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2jk5"
Personal tools