2jot
From Proteopedia
(Difference between revisions)
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<StructureSection load='2jot' size='340' side='right'caption='[[2jot]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | <StructureSection load='2jot' size='340' side='right'caption='[[2jot]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2jot]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2jot]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Chinese_bird_spider Chinese bird spider]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JOT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JOT FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jot FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jot OCA], [https://pdbe.org/2jot PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jot RCSB], [https://www.ebi.ac.uk/pdbsum/2jot PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jot ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/VKT1A_HAPSC VKT1A_HAPSC]] Dual-function toxin that inhibits both serine proteases (trypsin) and voltage-gated potassium channels (Kv). The toxin is more active on Kv1.1/KCNA1 (78% inhibition), than on Kv1.2/KCNA2 (10% inhibition), and Kv1.3/KCNA3 (28% inhibition), although a high dose (5 uM) is needed. The inhibition of potassium channels is voltage-dependent.<ref>PMID:15066414</ref> <ref>PMID:16820861</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Revision as of 08:15, 19 January 2022
Nuclear Magnetic Resonance Studies on Huwentoxin-XI from the Chinese Bird Spider Ornithoctonus huwena
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