This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3bqn
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==LFA-1 I domain bound to inhibitors== | ==LFA-1 I domain bound to inhibitors== | ||
| - | <StructureSection load='3bqn' size='340' side='right' caption='[[3bqn]], [[Resolution|resolution]] 1.80Å' scene=''> | + | <StructureSection load='3bqn' size='340' side='right'caption='[[3bqn]], [[Resolution|resolution]] 1.80Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3bqn]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3bqn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BQN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BQN FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BQN:4-{(2E)-3-[4-{[2-(PYRIDIN-3-YLMETHOXY)PHENYL]SULFANYL}-2,3-BIS(TRIFLUOROMETHYL)PHENYL]PROP-2-ENOYL}MORPHOLINE'>BQN</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BQN:4-{(2E)-3-[4-{[2-(PYRIDIN-3-YLMETHOXY)PHENYL]SULFANYL}-2,3-BIS(TRIFLUOROMETHYL)PHENYL]PROP-2-ENOYL}MORPHOLINE'>BQN</scene></td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3bqm|3bqm]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3bqm|3bqm]]</div></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ITGAL, CD11A ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ITGAL, CD11A ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bqn OCA], [https://pdbe.org/3bqn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bqn RCSB], [https://www.ebi.ac.uk/pdbsum/3bqn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bqn ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/ITAL_HUMAN ITAL_HUMAN]] Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 32: | Line 32: | ||
==See Also== | ==See Also== | ||
| - | *[[Integrin|Integrin]] | + | *[[Integrin 3D structures|Integrin 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
| Line 38: | Line 38: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Silvian, L F]] | [[Category: Silvian, L F]] | ||
[[Category: Cell adhesion]] | [[Category: Cell adhesion]] | ||
Revision as of 08:22, 19 January 2022
LFA-1 I domain bound to inhibitors
| |||||||||||
