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3bs5

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Current revision (08:23, 19 January 2022) (edit) (undo)
 
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==Crystal Structure of hCNK2-SAM/dHYP-SAM Complex==
==Crystal Structure of hCNK2-SAM/dHYP-SAM Complex==
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<StructureSection load='3bs5' size='340' side='right' caption='[[3bs5]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='3bs5' size='340' side='right'caption='[[3bs5]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3bs5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BS5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BS5 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3bs5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drome Drome] and [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BS5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BS5 FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3bs7|3bs7]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3bs7|3bs7]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ave ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME]), CNKSR2, CNK2, KIAA0902, KSR2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ave ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME]), CNKSR2, CNK2, KIAA0902, KSR2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bs5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bs5 OCA], [http://pdbe.org/3bs5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3bs5 RCSB], [http://www.ebi.ac.uk/pdbsum/3bs5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3bs5 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bs5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bs5 OCA], [https://pdbe.org/3bs5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bs5 RCSB], [https://www.ebi.ac.uk/pdbsum/3bs5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bs5 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/AVE_DROME AVE_DROME]] Required for normal photoreceptor differentiation between Ras and Raf for EGFR signaling in the eye and for mitogen-activated protein kinase phosphorylation. Probably acts together with Cnk to promote Raf activation, perhaps by recruiting an activating kinase. [[http://www.uniprot.org/uniprot/CNKR2_HUMAN CNKR2_HUMAN]] May function as an adapter protein or regulator of Ras signaling pathways.<ref>PMID:14597674</ref>
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[[https://www.uniprot.org/uniprot/AVE_DROME AVE_DROME]] Required for normal photoreceptor differentiation between Ras and Raf for EGFR signaling in the eye and for mitogen-activated protein kinase phosphorylation. Probably acts together with Cnk to promote Raf activation, perhaps by recruiting an activating kinase. [[https://www.uniprot.org/uniprot/CNKR2_HUMAN CNKR2_HUMAN]] May function as an adapter protein or regulator of Ras signaling pathways.<ref>PMID:14597674</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Drome]]
[[Category: Drome]]
[[Category: Human]]
[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Ceccarelli, D F]]
[[Category: Ceccarelli, D F]]
[[Category: Kurinov, I]]
[[Category: Kurinov, I]]

Current revision

Crystal Structure of hCNK2-SAM/dHYP-SAM Complex

PDB ID 3bs5

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