Spike protein
From Proteopedia
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== Function == | == Function == | ||
| - | The coronavirus '''spike protein''' (Spi, also called ''protein S'') binds the virus to its host cell via the cell's receptor: angiotensin-converting enzyme 2 (ACE2). The trimeric 2019-nCoV Spi binds to ACE2 at least 10 times more tightly than SARS coronavirus <ref>PMID:32075877</ref>. See also [[Angiotensin-Converting Enzyme#ACEII and SARS|ACEII and SARS]] | + | The coronavirus '''spike protein''' (Spi, also called ''protein S'') binds the virus to its host cell via the cell's receptor: angiotensin-converting enzyme 2 (ACE2). The trimeric 2019-nCoV Spi binds to ACE2 at least 10 times more tightly than SARS coronavirus <ref>PMID:32075877</ref>. See also |
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| + | *[[Angiotensin-Converting Enzyme#ACEII and SARS|ACEII and SARS]]<br /> | ||
| + | *[[SARS-CoV-2 protein S]]<br /> | ||
| + | *[[SARS-CoV-2 spike protein mutations]]<br /> | ||
| + | * and the animation at [[SARS-CoV-2 protein S priming by furin]]. | ||
== Disease == | == Disease == | ||
Revision as of 09:26, 24 January 2022
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See Also
- SARS-CoV-2 protein S
- SARS-CoV-2 protein S priming by furin where the priming step induced by furin cleavage is animated.
- SARS-CoV-2 spike protein fusion transformation with an animation and explanation of the membrane fusion mechanism.
- SARS-CoV-2 spike protein mutations
- Coronavirus Disease 2019 (COVID-19)
- Prefusion 2019-nCoV spike glycoprotein with a single receptor-binding domain up about 6vsb
- Spike Protein (Hebrew)
3D Structures of spike protein
Updated on 24-January-2022
References
- ↑ Wrapp D, Wang N, Corbett KS, Goldsmith JA, Hsieh CL, Abiona O, Graham BS, McLellan JS. Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation. Science. 2020 Feb 19. pii: science.abb2507. doi: 10.1126/science.abb2507. PMID:32075877 doi:http://dx.doi.org/10.1126/science.abb2507
- ↑ Tian X, Li C, Huang A, Xia S, Lu S, Shi Z, Lu L, Jiang S, Yang Z, Wu Y, Ying T. Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody. Emerg Microbes Infect. 2020 Feb 17;9(1):382-385. doi:, 10.1080/22221751.2020.1729069. eCollection 2020. PMID:32065055 doi:http://dx.doi.org/10.1080/22221751.2020.1729069
- ↑ Wu K, Li W, Peng G, Li F. Crystal structure of NL63 respiratory coronavirus receptor-binding domain complexed with its human receptor. Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):19970-4. Epub 2009 Nov 9. PMID:19901337
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