1g6l

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[[Image:1g6l.gif|left|200px]]
[[Image:1g6l.gif|left|200px]]
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{{Structure
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|PDB= 1g6l |SIZE=350|CAPTION= <scene name='initialview01'>1g6l</scene>, resolution 1.9&Aring;
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The line below this paragraph, containing "STRUCTURE_1g6l", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] </span>
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{{STRUCTURE_1g6l| PDB=1g6l | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1g6l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g6l OCA], [http://www.ebi.ac.uk/pdbsum/1g6l PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1g6l RCSB]</span>
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'''1.9A CRYSTAL STRUCTURE OF TETHERED HIV-1 PROTEASE'''
'''1.9A CRYSTAL STRUCTURE OF TETHERED HIV-1 PROTEASE'''
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[[Category: Kannan, K K.]]
[[Category: Kannan, K K.]]
[[Category: Pillai, B.]]
[[Category: Pillai, B.]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:12:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:37:42 2008''
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Revision as of 14:12, 2 May 2008

Image:1g6l.gif

Template:STRUCTURE 1g6l

1.9A CRYSTAL STRUCTURE OF TETHERED HIV-1 PROTEASE


Overview

Three-dimensional structure of an asymmetrically mutated (C95M) tethered human immunodeficiency virus type 1 protease enzyme (HIV-1 PR) has been determined in an unliganded form using X-ray diffraction data to 1.9 A resolution. The structure, refined using X-PLOR to an R factor of 19.5%, is unexpectedly similar to the ligand-bound native enzyme, rather than to the ligand-free native enzyme. In particular, the two flaps in the tethered dimer are in a closed configuration. The environments around M95 and C1095 are identical, showing no structural effect of this asymmetric mutation at position 95. Oxidation of Cys1095 has been observed for the first time. There is one well-defined water molecule that hydrogen bonds to both carboxyl groups of the essential aspartic acids in the active site. Proteins 2001;43:57-64.

About this Structure

1G6L is a Single protein structure of sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

1.9 A x-ray study shows closed flap conformation in crystals of tethered HIV-1 PR., Pillai B, Kannan KK, Hosur MV, Proteins. 2001 Apr 1;43(1):57-64. PMID:11170214 Page seeded by OCA on Fri May 2 17:12:12 2008

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