1g6t

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[[Image:1g6t.jpg|left|200px]]
[[Image:1g6t.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1g6t |SIZE=350|CAPTION= <scene name='initialview01'>1g6t</scene>, resolution 1.60&Aring;
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The line below this paragraph, containing "STRUCTURE_1g6t", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=S3P:SHIKIMATE-3-PHOSPHATE'>S3P</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/3-phosphoshikimate_1-carboxyvinyltransferase 3-phosphoshikimate 1-carboxyvinyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.19 2.5.1.19] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= AROA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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-->
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|DOMAIN=
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{{STRUCTURE_1g6t| PDB=1g6t | SCENE= }}
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|RELATEDENTRY=[[1g6s|1G6S]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1g6t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g6t OCA], [http://www.ebi.ac.uk/pdbsum/1g6t PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1g6t RCSB]</span>
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}}
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'''STRUCTURE OF EPSP SYNTHASE LIGANDED WITH SHIKIMATE-3-PHOSPHATE'''
'''STRUCTURE OF EPSP SYNTHASE LIGANDED WITH SHIKIMATE-3-PHOSPHATE'''
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[[Category: Schonbrunn, E.]]
[[Category: Schonbrunn, E.]]
[[Category: Shuttleworth, W.]]
[[Category: Shuttleworth, W.]]
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[[Category: inside-out alpha-beta barrel]]
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[[Category: Inside-out alpha-beta barrel]]
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[[Category: two-domain structure]]
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[[Category: Two-domain structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:12:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:37:47 2008''
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Revision as of 14:12, 2 May 2008

Image:1g6t.jpg

Template:STRUCTURE 1g6t

STRUCTURE OF EPSP SYNTHASE LIGANDED WITH SHIKIMATE-3-PHOSPHATE


Overview

Biosynthesis of aromatic amino acids in plants, many bacteria, and microbes relies on the enzyme 5-enolpyruvylshikimate 3-phosphate (EPSP) synthase, a prime target for drugs and herbicides. We have identified the interaction of EPSP synthase with one of its two substrates (shikimate 3-phosphate) and with the widely used herbicide glyphosate by x-ray crystallography. The two-domain enzyme closes on ligand binding, thereby forming the active site in the interdomain cleft. Glyphosate appears to occupy the binding site of the second substrate of EPSP synthase (phosphoenol pyruvate), mimicking an intermediate state of the ternary enzyme.substrates complex. The elucidation of the active site of EPSP synthase and especially of the binding pattern of glyphosate provides a valuable roadmap for engineering new herbicides and herbicide-resistant crops, as well as new antibiotic and antiparasitic drugs.

About this Structure

1G6T is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Interaction of the herbicide glyphosate with its target enzyme 5-enolpyruvylshikimate 3-phosphate synthase in atomic detail., Schonbrunn E, Eschenburg S, Shuttleworth WA, Schloss JV, Amrhein N, Evans JN, Kabsch W, Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1376-80. PMID:11171958 Page seeded by OCA on Fri May 2 17:12:46 2008

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