1g7c

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[[Image:1g7c.jpg|left|200px]]
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{{Structure
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|PDB= 1g7c |SIZE=350|CAPTION= <scene name='initialview01'>1g7c</scene>, resolution 2.05&Aring;
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The line below this paragraph, containing "STRUCTURE_1g7c", creates the "Structure Box" on the page.
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|LIGAND= <scene name='pdbligand=5GP:GUANOSINE-5&#39;-MONOPHOSPHATE'>5GP</scene>
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|GENE= TEF5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])
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{{STRUCTURE_1g7c| PDB=1g7c | SCENE= }}
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|RELATEDENTRY=[[1f60|1F60]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1g7c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g7c OCA], [http://www.ebi.ac.uk/pdbsum/1g7c PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1g7c RCSB]</span>
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'''YEAST EEF1A:EEF1BA IN COMPLEX WITH GDPNP'''
'''YEAST EEF1A:EEF1BA IN COMPLEX WITH GDPNP'''
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[[Category: Pedersen, L.]]
[[Category: Pedersen, L.]]
[[Category: Valente, L.]]
[[Category: Valente, L.]]
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[[Category: protein-protein complex]]
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[[Category: Protein-protein complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:13:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:38:13 2008''
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Revision as of 14:13, 2 May 2008

Image:1g7c.jpg

Template:STRUCTURE 1g7c

YEAST EEF1A:EEF1BA IN COMPLEX WITH GDPNP


Overview

In the elongation cycle of protein biosynthesis, the nucleotide exchange factor eEF1Balpha catalyzes the exchange of GDP bound to the G-protein, eEF1A, for GTP. To obtain more information about the recently solved eEF1A-eEF1Balpha structure, we determined the structures of the eEF1A-eEF1Balpha-GDP-Mg2+, eEF1A-eEF1Balpha-GDP and eEF1A-eEF1Balpha-GDPNP complexes at 3.0, 2.4 and 2.05 A resolution, respectively. Minor changes, specifically around the nucleotide binding site, in eEF1A and eEF1Balpha are consistent with in vivo data. The base, sugar and alpha-phosphate bind as in other known nucleotide G-protein complexes, whereas the beta- and gamma-phosphates are disordered. A mutation of Lys 205 in eEF1Balpha that inserts into the Mg2+ binding site of eEF1A is lethal. This together with the structures emphasizes the essential role of Mg2+ in nucleotide exchange in the eEF1A-eEF1Balpha complex.

About this Structure

1G7C is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Crystal structures of nucleotide exchange intermediates in the eEF1A-eEF1Balpha complex., Andersen GR, Valente L, Pedersen L, Kinzy TG, Nyborg J, Nat Struct Biol. 2001 Jun;8(6):531-4. PMID:11373622 Page seeded by OCA on Fri May 2 17:13:56 2008

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