1g7p

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1g7p.gif|left|200px]]
[[Image:1g7p.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1g7p |SIZE=350|CAPTION= <scene name='initialview01'>1g7p</scene>, resolution 1.50&Aring;
+
The line below this paragraph, containing "STRUCTURE_1g7p", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Alpha-glucosidase Alpha-glucosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.20 3.2.1.20] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1g7p| PDB=1g7p | SCENE= }}
-
|RELATEDENTRY=[[2vab|2VAB]], [[1vad|1VAD]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1g7p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g7p OCA], [http://www.ebi.ac.uk/pdbsum/1g7p PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1g7p RCSB]</span>
+
-
}}
+
'''CRYSTAL STRUCTURE OF MHC CLASS I H-2KB HEAVY CHAIN COMPLEXED WITH BETA-2 MICROGLOBULIN AND YEAST ALPHA-GLUCOSIDASE'''
'''CRYSTAL STRUCTURE OF MHC CLASS I H-2KB HEAVY CHAIN COMPLEXED WITH BETA-2 MICROGLOBULIN AND YEAST ALPHA-GLUCOSIDASE'''
Line 33: Line 30:
[[Category: Wilson, I A.]]
[[Category: Wilson, I A.]]
[[Category: Yu, M.]]
[[Category: Yu, M.]]
-
[[Category: alpha-glucosidase]]
+
[[Category: Alpha-glucosidase]]
-
[[Category: h-2kb]]
+
[[Category: H-2kb]]
-
[[Category: mhc class i]]
+
[[Category: Mhc class i]]
-
[[Category: s. cerevisiae]]
+
[[Category: S. cerevisiae]]
-
[[Category: yeast]]
+
[[Category: Yeast]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:14:40 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:38:21 2008''
+

Revision as of 14:14, 2 May 2008

Image:1g7p.gif

Template:STRUCTURE 1g7p

CRYSTAL STRUCTURE OF MHC CLASS I H-2KB HEAVY CHAIN COMPLEXED WITH BETA-2 MICROGLOBULIN AND YEAST ALPHA-GLUCOSIDASE


Overview

The crystal structure of a non-standard peptide, YEA9, in complex with H-2Kb, at 1.5 A resolution demonstrates how YEA9 peptide can bind with surprisingly high affinity through insertion of alternative, long, non-canonical anchors into the B and E pockets. The use of "alternative pockets" represents a new mode of high affinity peptide binding, that should be considered when predicting peptide epitopes for MHC class I. These novel interactions encountered in this non-canonical high affinity peptide-MHC complex should help predict additional binding peptides from primary protein sequences and aid in the design of alternative approaches for peptide-based vaccines.

About this Structure

1G7P is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of a non-canonical high affinity peptide complexed with MHC class I: a novel use of alternative anchors., Apostolopoulos V, Yu M, Corper AL, Li W, McKenzie IF, Teyton L, Wilson IA, Plebanski M, J Mol Biol. 2002 May 17;318(5):1307-16. PMID:12083519 Page seeded by OCA on Fri May 2 17:14:40 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1g7p"
Personal tools