1g7s

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[[Image:1g7s.jpg|left|200px]]
[[Image:1g7s.jpg|left|200px]]
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{{Structure
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|PDB= 1g7s |SIZE=350|CAPTION= <scene name='initialview01'>1g7s</scene>, resolution 2.&Aring;
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The line below this paragraph, containing "STRUCTURE_1g7s", creates the "Structure Box" on the page.
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|LIGAND= <scene name='pdbligand=GDP:GUANOSINE-5&#39;-DIPHOSPHATE'>GDP</scene>
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{{STRUCTURE_1g7s| PDB=1g7s | SCENE= }}
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|RELATEDENTRY=[[1g7r|1G7R]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1g7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g7s OCA], [http://www.ebi.ac.uk/pdbsum/1g7s PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1g7s RCSB]</span>
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'''X-RAY STRUCTURE OF TRANSLATION INITIATION FACTOR IF2/EIF5B COMPLEXED WITH GDP'''
'''X-RAY STRUCTURE OF TRANSLATION INITIATION FACTOR IF2/EIF5B COMPLEXED WITH GDP'''
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[[Category: Dever, T E.]]
[[Category: Dever, T E.]]
[[Category: Roll-Mecak, A.]]
[[Category: Roll-Mecak, A.]]
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[[Category: translational gtpase]]
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[[Category: Translational gtpase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:14:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:38:27 2008''
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Revision as of 14:15, 2 May 2008

Image:1g7s.jpg

Template:STRUCTURE 1g7s

X-RAY STRUCTURE OF TRANSLATION INITIATION FACTOR IF2/EIF5B COMPLEXED WITH GDP


Overview

X-ray structures of the universal translation initiation factor IF2/eIF5B have been determined in three states: free enzyme, inactive IF2/eIF5B.GDP, and active IF2/eIF5B.GTP. The "chalice-shaped" enzyme is a GTPase that facilitates ribosomal subunit joining and Met-tRNA(i) binding to ribosomes in all three kingdoms of life. The conserved core of IF2/eIF5B consists of an N-terminal G domain (I) plus an EF-Tu-type beta barrel (II), followed by a novel alpha/beta/alpha-sandwich (III) connected via an alpha helix to a second EF-Tu-type beta barrel (IV). Structural comparisons reveal a molecular lever, which amplifies a modest conformational change in the Switch 2 region of the G domain induced by Mg(2+)/GTP binding over a distance of 90 A from the G domain active center to domain IV. Mechanisms of GTPase function and ribosome binding are discussed.

About this Structure

1G7S is a Single protein structure of sequence from Methanothermobacter thermautotrophicus. Full crystallographic information is available from OCA.

Reference

X-Ray structures of the universal translation initiation factor IF2/eIF5B: conformational changes on GDP and GTP binding., Roll-Mecak A, Cao C, Dever TE, Burley SK, Cell. 2000 Nov 22;103(5):781-92. PMID:11114334 Page seeded by OCA on Fri May 2 17:14:56 2008

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