1g8f

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[[Image:1g8f.jpg|left|200px]]
[[Image:1g8f.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1g8f |SIZE=350|CAPTION= <scene name='initialview01'>1g8f</scene>, resolution 1.95&Aring;
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The line below this paragraph, containing "STRUCTURE_1g8f", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Sulfate_adenylyltransferase Sulfate adenylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.4 2.7.7.4] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1g8f| PDB=1g8f | SCENE= }}
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|RELATEDENTRY=[[1g8g|1G8G]], [[1g8h|1G8H]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1g8f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g8f OCA], [http://www.ebi.ac.uk/pdbsum/1g8f PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1g8f RCSB]</span>
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}}
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'''ATP SULFURYLASE FROM S. CEREVISIAE'''
'''ATP SULFURYLASE FROM S. CEREVISIAE'''
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[[Category: Huber, R.]]
[[Category: Huber, R.]]
[[Category: Ullrich, T C.]]
[[Category: Ullrich, T C.]]
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[[Category: alpha-beta protein]]
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[[Category: Alpha-beta protein]]
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[[Category: beta-barrel]]
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[[Category: Beta-barrel]]
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[[Category: kinase fold]]
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[[Category: Kinase fold]]
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[[Category: rossmann-fold]]
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[[Category: Rossmann-fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:16:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:38:56 2008''
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Revision as of 14:16, 2 May 2008

Image:1g8f.jpg

Template:STRUCTURE 1g8f

ATP SULFURYLASE FROM S. CEREVISIAE


Overview

ATP sulfurylases (ATPSs) are ubiquitous enzymes that catalyse the primary step of intracellular sulfate activation: the reaction of inorganic sulfate with ATP to form adenosine-5'-phosphosulfate (APS) and pyrophosphate (PPi). With the crystal structure of ATPS from the yeast Saccharomyces cerevisiae, we have solved the first structure of a member of the ATP sulfurylase family. We have analysed the crystal structure of the native enzyme at 1.95 Angstroms resolution using multiple isomorphous replacement (MIR) and, subsequently, the ternary enzyme product complex with APS and PPi bound to the active site. The enzyme consists of six identical subunits arranged in two stacked rings in a D:3 symmetric assembly. Nucleotide binding causes significant conformational changes, which lead to a rigid body structural displacement of domains III and IV of the ATPS monomer. Despite having similar folds and active site design, examination of the active site of ATPS and comparison with known structures of related nucleotidylyl transferases reveal a novel ATP binding mode that is peculiar to ATP sulfurylases.

About this Structure

1G8F is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Crystal structure of ATP sulfurylase from Saccharomyces cerevisiae, a key enzyme in sulfate activation., Ullrich TC, Blaesse M, Huber R, EMBO J. 2001 Feb 1;20(3):316-29. PMID:11157739 Page seeded by OCA on Fri May 2 17:16:25 2008

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