7ppj
From Proteopedia
(Difference between revisions)
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==human SLFN5== | ==human SLFN5== | ||
| - | <StructureSection load='7ppj' size='340' side='right'caption='[[7ppj]]' scene=''> | + | <StructureSection load='7ppj' size='340' side='right'caption='[[7ppj]], [[Resolution|resolution]] 3.44Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7PPJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7PPJ FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7ppj]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7PPJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7PPJ FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ppj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ppj OCA], [https://pdbe.org/7ppj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ppj RCSB], [https://www.ebi.ac.uk/pdbsum/7ppj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ppj ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[6rr9|6rr9]]</div></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ppj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ppj OCA], [https://pdbe.org/7ppj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ppj RCSB], [https://www.ebi.ac.uk/pdbsum/7ppj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ppj ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/SLFN5_HUMAN SLFN5_HUMAN]] May have a role in hematopoietic cell differentiation. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The Schlafen family belongs to the interferon-stimulated genes and its members are involved in cell cycle regulation, T cell quiescence, inhibition of viral replication, DNA-repair and tRNA processing. Here, we present the cryo-EM structure of full-length human Schlafen 5 (SLFN5) and the high-resolution crystal structure of the highly conserved N-terminal core domain. We show that the core domain does not resemble an ATPase-like fold and neither binds nor hydrolyzes ATP. SLFN5 binds tRNA as well as single- and double-stranded DNA, suggesting a potential role in transcriptional regulation. Unlike rat Slfn13 or human SLFN11, human SLFN5 did not cleave tRNA. Based on the structure, we identified two residues in proximity to the zinc finger motif that decreased DNA binding when mutated. These results indicate that Schlafen proteins have divergent enzymatic functions and provide a structural platform for future biochemical and genetic studies. | ||
| + | |||
| + | Structural and biochemical characterization of human Schlafen 5.,Metzner FJ, Huber E, Hopfner KP, Lammens K Nucleic Acids Res. 2022 Jan 25;50(2):1147-1161. doi: 10.1093/nar/gkab1278. PMID:35037067<ref>PMID:35037067</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7ppj" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Lammens K]] | + | [[Category: Lammens, K]] |
| - | [[Category: Metzner | + | [[Category: Metzner, F J]] |
| + | [[Category: Dna binding protein]] | ||
| + | [[Category: Nucleotide binding protein antiviral linked to tumorigenesis transcription regulation]] | ||
Revision as of 07:14, 2 February 2022
human SLFN5
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