3cok

<StructureSection load='3cok' size='340' side='right' caption='[[3cok]], [[Resolution|resolution]] 2.25&Aring;' scene=''>

<table><tr><td colspan='2'>[[3cok]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3COK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3COK FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3cok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cok OCA], [http://pdbe.org/3cok PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3cok RCSB], [http://www.ebi.ac.uk/pdbsum/3cok PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3cok ProSAT], [http://www.topsan.org/Proteins/NYSGXRC/3cok TOPSAN]</span></td></tr>

== Function ==

[[http://www.uniprot.org/uniprot/PLK4_HUMAN PLK4_HUMAN]] Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2.<ref>PMID:16326102</ref> <ref>PMID:16244668</ref> <ref>PMID:17681131</ref> <ref>PMID:18239451</ref> <ref>PMID:19164942</ref> <ref>PMID:21725316</ref>

*[[Serine/threonine protein kinase|Serine/threonine protein kinase]]

[[Category: Human]]

[[Category: Polo kinase]]

[[Category: Atwell, S]]

[[Category: Burley, S K]]

[[Category: Houle, A]]

[[Category: Leon, B]]

[[Category: Structural genomic]]

[[Category: Pelletier, L A]]

[[Category: Sauder, J M]]

[[Category: Transferase]]