This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1dk8

From Proteopedia

(Difference between revisions)
Jump to: navigation, search

OCA (Talk | contribs)
(New page: 200px<br /> <applet load="1dk8" size="450" color="white" frame="true" align="right" spinBox="true" caption="1dk8, resolution 1.57&Aring;" /> '''CRYSTAL STRUCTURE O...)
Next diff →

Revision as of 14:26, 12 November 2007

Image:1dk8.gif

1dk8, resolution 1.57Å

Drag the structure with the mouse to rotate

CRYSTAL STRUCTURE OF THE RGS-HOMOLOGOUS DOMAIN OF AXIN

Contents

Overview

Axin and the adenomatous polyposis coli (APC) tumor suppressor protein are, components of the Wnt/Wingless growth factor signaling pathway. In the, absence of Wnt signal, Axin and APC regulate cytoplasmic levels of the, proto-oncogene beta-catenin through the formation of a large complex, containing these three proteins, glycogen synthase kinase 3beta (GSK3beta), and several other proteins. Both Axin and APC are known to be critical for, beta-catenin regulation, and truncations in APC that eliminate the, Axin-binding site result in human cancers. A protease-resistant domain of, Axin that contains the APC-binding site is a member of the regulators of, G-protein signaling (RGS) superfamily. The crystal structures of this, domain alone and in complex with an Axin-binding sequence from APC reveal, that the Axin-APC interaction occurs at a conserved groove on a face of, the protein that is distinct from the G-protein interface of classical RGS, proteins. The molecular interactions observed in the Axin-APC complex, provide a rationale for the evolutionary conservation seen in both, proteins.

Disease

Known diseases associated with this structure: Caudal duplication anomaly OMIM:[603816], Hepatocellular carcinoma, somatic OMIM:[603816]

About this Structure

1DK8 is a Single protein structure of sequence from Homo sapiens with SO4, DTT and GOL as ligands. Full crystallographic information is available from OCA.

Reference

Structural basis of the Axin-adenomatous polyposis coli interaction., Spink KE, Polakis P, Weis WI, EMBO J. 2000 May 15;19(10):2270-9. PMID:10811618

Page seeded by OCA on Mon Nov 12 16:33:19 2007

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1dk8"
Personal tools