Sandbox Test M

From Proteopedia

Revision as of 17:38, 3 February 2022

AlphaFold2 Model of Sars-CoV-2 Protein M

spinqualitylabelsall models Caption for this structure Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Theoretical Model: The protein structure described on this page was determined theoretically, and hence should be interpreted with caution. Model Confidence:   Very high (pLDDT > 90)   Confident (90 > pLDDT > 70)   Low (70 > pLDDT > 50)   Very low (pLDDT < 50) AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions below 50 pLDDT may be unstructured in isolation. To the right is an AlphaFold2 3D model of SARS CoV-2 Protein (UniProt ID: QHD43419) color coded by the pLDDT scores. It corresponds to the highest ranked model in terms of the pLDDT confidence scores, i.e., model 4[1]. Function Disease Function Protein M Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.[2][3]] Disease Relevance Structural highlights Morph of the top 5 ranked AlphaFold2 models of SARS-CoV-2 Protein M, rainbow color coded N-C[1]. See also Coronavirus_Disease 2019 (COVID-19)

References

1. ↑ ^{1.0 1.1} MIT ColabFold https://colab.research.google.com/github/sokrypton/ColabFold/blob/main/beta/AlphaFold2_advanced.ipynb
2. ↑ Modeling of the SARS-COV-2 Genome
3. ↑ Zhang C, Zheng W, Huang X, Bell EW, Zhou X, Zhang Y. Protein Structure and Sequence Reanalysis of 2019-nCoV Genome Refutes Snakes as Its Intermediate Host and the Unique Similarity between Its Spike Protein Insertions and HIV-1. J Proteome Res. 2020 Apr 3;19(4):1351-1360. doi: 10.1021/acs.jproteome.0c00129., Epub 2020 Mar 24. PMID:32200634 doi:http://dx.doi.org/10.1021/acs.jproteome.0c00129