COVID-19 AlphaFold2 Models

Theoretical Model: The protein structure described on this page was determined theoretically, and hence should be interpreted with caution.

To the right is an AlphaFold2 3D model of the SARS CoV-2 Protein N (UniProt ID: QHD43423) color coded by the pLDDT scores. It corresponds to the highest ranked model in terms of the pLDDT confidence scores, i.e., model 5^[1].

At present a number of proteins of the SARS CoV-2 virus have still not been experimentally determined. AlphaFold2 was used to predict 3D models for these proteins using the MIT ColabFold server^[1] . For each prediction, five 3D models were predicted, ranked 1 to 5 (with 1 being the best). An example of such a predicted structure is the SARS CoV-2 Protein N (UniProt ID: QHD43423) color coded by the pLDDT scores. Views of these AlphaFold2 predictions can be seen on the following Proteopedia pages:

SARS-CoV-2 protein M - Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.Cite error: Invalid <ref> tag; invalid names, e.g. too many^[2].

SARS-CoV-2 protein N - The primary function of the Nucleocapsid protein (N-protein) is to package the viral genome into a helical ribonucleoprotein (RNP) complexCite error: Invalid <ref> tag;

invalid names, e.g. too many^[3]]