SARS-CoV-2 protein NSP2
From Proteopedia
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== Function == | == Function == | ||
'''Non-structural protein 2 (nsp2)''' | '''Non-structural protein 2 (nsp2)''' | ||
| - | May play a role in the modulation of host cell survival signaling pathway by interacting with host PHB and PHB2. Indeed, these two proteins play a role in maintaining the functional integrity of the mitochondria and protecting cells from various stresses.<ref>[https://zhanglab.ccmb.med.umich.edu/COVID-19/ Modeling of the SARS-COV-2 Genome]</ref><ref>pmid 32200634</ref>. The structure was determined by a combination of CryoEM and AI by the QBI Coronavrus Research Group ([http://qbi.ucsf.edu/QCRG/overview# QCRG]). | + | May play a role in the modulation of host cell survival signaling pathway by interacting with host PHB and PHB2. Indeed, these two proteins play a role in maintaining the functional integrity of the mitochondria and protecting cells from various stresses.<ref>[https://zhanglab.ccmb.med.umich.edu/COVID-19/ Modeling of the SARS-COV-2 Genome]</ref><ref>pmid 32200634</ref>. |
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| + | == Structure Determination == | ||
| + | The structure was determined by a combination of CryoEM and AI by the QBI Coronavrus Research Group ([http://qbi.ucsf.edu/QCRG/overview# QCRG]). | ||
== See also == | == See also == | ||
Revision as of 08:53, 6 February 2022
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References
- ↑ Modeling of the SARS-COV-2 Genome
- ↑ Zhang C, Zheng W, Huang X, Bell EW, Zhou X, Zhang Y. Protein Structure and Sequence Reanalysis of 2019-nCoV Genome Refutes Snakes as Its Intermediate Host and the Unique Similarity between Its Spike Protein Insertions and HIV-1. J Proteome Res. 2020 Apr 3;19(4):1351-1360. doi: 10.1021/acs.jproteome.0c00129., Epub 2020 Mar 24. PMID:32200634 doi:http://dx.doi.org/10.1021/acs.jproteome.0c00129
