Serine/threonine protein kinase 3D structures
From Proteopedia
(Difference between revisions)
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**[[1nvq]], [[1nvr]] – hChk1 kinase domain + peptide + saurosporine | **[[1nvq]], [[1nvr]] – hChk1 kinase domain + peptide + saurosporine | ||
| - | **[[1nvs]], [[1zys]] - hChk1 kinase domain + peptide + inhibitor | + | **[[1nvs]], [[1zys]], [[7ako]] - hChk1 kinase domain + peptide + inhibitor |
| + | **[[7akm]] - hChk1 kinase domain + ATP<br /> | ||
**[[2cgu]], [[2cgv]], [[2cgw]], [[2cgx]], [[2c3j]], [[2c3k]], [[2c3l]], [[2br1]], [[2brb]], [[2brg]], [[2brh]], [[2brm]], [[2brn]], [[2bro]], [[2ayp]], [[2gdo]], [[2ghg]], [[2hog]], [[2ywp]], [[2hxl]], [[2hxq]], [[2hy0]], [[2r0u]], [[2e9n]], [[2e9o]], [[2e9p]], [[2e9u]], [[2e9v]], [[2qhm]], [[2qhn]], [[3f9n]], [[2wmq]], [[2wmr]], [[2wms]], [[2wmt]], [[2wmu]], [[2wmv]], [[2wmx]], [[3jvr]], [[3jvs]], [[2xey]], [[2xf0]], [[2xez]], [[2x8d]], [[2x8e]], [[2x8i]], [[3ot3]], [[3ot8]], [[3pa3]], [[3pa4]], [[3pa5]], [[3nlb]], [[2wmw]], [[2ydi]], [[2ydj]], [[2ydk]], [[2yer]], [[2yex]], [[2ym3]], [[2ym4]], [[2ym5]], [[2ym6]], [[2ym7]], [[2ym8]], [[3tkh]], [[3tki]], [[3u9n]], [[4fsm]], [[4fsn]], [[4fsq]], [[4fsr]], [[4fst]], [[4fsu]], [[4fsw]], [[4fsy]], [[4fsz]], [[4ft0]], [[4ft3]], [[4ft5]], [[4ft7]], [[4ft9]], [[4fta]], [[4ftc]], [[4fti]], [[4ftj]], [[4ftk]], [[4ftl]], [[4ftm]], [[4ftn]], [[4fto]], [[4ftq]], [[4ftr]], [[4ftt]], [[4ftu]], [[4gh2]], [[4hyh]], [[4hyi]], [[4jik]], [[4rvm]], [[4rvl]], [[4rvk]], [[4qyh]], [[4qyg]], [[4qyf]], [[4qye]], [[5dls]], [[5f4n]], [[6fc8]], [[5fcf]], [[5fck]], [[6fck]], [[6fcf]] - hChk1 kinase domain + inhibitor<br /> | **[[2cgu]], [[2cgv]], [[2cgw]], [[2cgx]], [[2c3j]], [[2c3k]], [[2c3l]], [[2br1]], [[2brb]], [[2brg]], [[2brh]], [[2brm]], [[2brn]], [[2bro]], [[2ayp]], [[2gdo]], [[2ghg]], [[2hog]], [[2ywp]], [[2hxl]], [[2hxq]], [[2hy0]], [[2r0u]], [[2e9n]], [[2e9o]], [[2e9p]], [[2e9u]], [[2e9v]], [[2qhm]], [[2qhn]], [[3f9n]], [[2wmq]], [[2wmr]], [[2wms]], [[2wmt]], [[2wmu]], [[2wmv]], [[2wmx]], [[3jvr]], [[3jvs]], [[2xey]], [[2xf0]], [[2xez]], [[2x8d]], [[2x8e]], [[2x8i]], [[3ot3]], [[3ot8]], [[3pa3]], [[3pa4]], [[3pa5]], [[3nlb]], [[2wmw]], [[2ydi]], [[2ydj]], [[2ydk]], [[2yer]], [[2yex]], [[2ym3]], [[2ym4]], [[2ym5]], [[2ym6]], [[2ym7]], [[2ym8]], [[3tkh]], [[3tki]], [[3u9n]], [[4fsm]], [[4fsn]], [[4fsq]], [[4fsr]], [[4fst]], [[4fsu]], [[4fsw]], [[4fsy]], [[4fsz]], [[4ft0]], [[4ft3]], [[4ft5]], [[4ft7]], [[4ft9]], [[4fta]], [[4ftc]], [[4fti]], [[4ftj]], [[4ftk]], [[4ftl]], [[4ftm]], [[4ftn]], [[4fto]], [[4ftq]], [[4ftr]], [[4ftt]], [[4ftu]], [[4gh2]], [[4hyh]], [[4hyi]], [[4jik]], [[4rvm]], [[4rvl]], [[4rvk]], [[4qyh]], [[4qyg]], [[4qyf]], [[4qye]], [[5dls]], [[5f4n]], [[6fc8]], [[5fcf]], [[5fck]], [[6fck]], [[6fcf]] - hChk1 kinase domain + inhibitor<br /> | ||
**[[5oot]], [[5op2]], [[5op4]], [[5op5]], [[5op7]], [[5opb]], [[5opr]], [[5ops]], [[5opu]], [[5opv]], [[5oq5]], [[5oq6]], [[5oq7]], [[5oq8]] - hChk1 kinase domain (mutant) + inhibitor<br /> | **[[5oot]], [[5op2]], [[5op4]], [[5op5]], [[5op7]], [[5opb]], [[5opr]], [[5ops]], [[5opu]], [[5opv]], [[5oq5]], [[5oq6]], [[5oq7]], [[5oq8]] - hChk1 kinase domain (mutant) + inhibitor<br /> | ||
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**[[6r49]] – hChk6 kinase domain (mutant) + PThr + CoA<br /> | **[[6r49]] – hChk6 kinase domain (mutant) + PThr + CoA<br /> | ||
| - | *'''Chk10 (lymphocyte-oriented kinase)''' | + | *'''Chk10 (lymphocyte-oriented kinase)''' or LOK or STK10 |
| - | **[[2j7t]], [[4aot]], [[4equ]], [[5ajq]], [[5owq]], [[5owr]], [[6eim]], [[6gtt]], [[6i2y]], [[6hxf]] – hChk10 kinase domain + inhibitor<br /> | + | **[[7qgp]] – hChk10 <br /> |
| + | **[[2j7t]], [[4aot]], [[4equ]], [[4usd]], [[4use]], [[5ajq]], [[5owq]], [[5owr]], [[6eim]], [[6gtt]], [[6i2y]], [[6hxf]] – hChk10 kinase domain + inhibitor<br /> | ||
| + | **[[4bc6]], [[6i2y]] – hChk10 + drug <br /> | ||
*'''Chk11''' | *'''Chk11''' | ||
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**[[2buj]] – hChk16 (mutant) + staurosporin <br /> | **[[2buj]] – hChk16 (mutant) + staurosporin <br /> | ||
| - | *'''Chk17B''' | + | *'''Chk17B''' or DRAK2 or STK17B |
**[[3lm0]] – hChk17B <br /> | **[[3lm0]] – hChk17B <br /> | ||
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**[[3lm5]] – hChk17B + quercetin<br /> | **[[3lm5]] – hChk17B + quercetin<br /> | ||
**[[6y6f]], [[6y6h]], [[6zjf]] – hChk17B + pyrimidine derivative<br /> | **[[6y6f]], [[6y6h]], [[6zjf]] – hChk17B + pyrimidine derivative<br /> | ||
| + | **[[7akg]] – hChk17B + drug<br /> | ||
*'''Chk24 (Mst3)''' | *'''Chk24 (Mst3)''' | ||
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*'''Chk26 (Mst4)''' | *'''Chk26 (Mst4)''' | ||
| - | **[[3ggf]] – hChk Mst4 + inhibitor <br /> | + | **[[3ggf]], [[7b36]] – hChk Mst4 + inhibitor <br /> |
**[[4geh]], [[3w8i]] - hChk Mst4 dimerization domain + programmed cell death protein 10<br /> | **[[4geh]], [[3w8i]] - hChk Mst4 dimerization domain + programmed cell death protein 10<br /> | ||
**[[4fza]], [[4fzd]], [[4fzf]] – hChk Mst4 (mutant) + calcium-binding protein <br /> | **[[4fza]], [[4fzd]], [[4fzf]] – hChk Mst4 (mutant) + calcium-binding protein <br /> | ||
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*'''B-Raf'''; domains - BRS 38-116; Ras-binding 153-237; kinase 445-723 | *'''B-Raf'''; domains - BRS 38-116; Ras-binding 153-237; kinase 445-723 | ||
| - | **[[1uwh]], [[3c4c]] – hB-Raf kinase domain + anticancer drug<br /> | + | **[[1uwh]], [[3c4c]], [[6v2u]] – hB-Raf kinase domain + anticancer drug<br /> |
**[[1uwj]] – hB-Raf kinase domain (mutant) + anticancer drug<br /> | **[[1uwj]] – hB-Raf kinase domain (mutant) + anticancer drug<br /> | ||
**[[2fb8]], [[3d4q]], [[3ii5]], [[3psd]], [[3skc]], [[3tv6]], [[4g9c]], [[4ksp]], [[4ksq]], [[3psb]], [[3ppj]], [[3ppk]], [[3prf]], [[3pri]], [[3tv4]], [[4dbn]], [[4e4x]], [[4mbj]], [[4ehe]], [[3q4c]], [[3q96]], [[3e26]], [[4h58]], [[4e26]], [[4fc0]], [[4pp7]], [[6cad]] – hB-Raf kinase domain + pyrazole inhibitor<br /> | **[[2fb8]], [[3d4q]], [[3ii5]], [[3psd]], [[3skc]], [[3tv6]], [[4g9c]], [[4ksp]], [[4ksq]], [[3psb]], [[3ppj]], [[3ppk]], [[3prf]], [[3pri]], [[3tv4]], [[4dbn]], [[4e4x]], [[4mbj]], [[4ehe]], [[3q4c]], [[3q96]], [[3e26]], [[4h58]], [[4e26]], [[4fc0]], [[4pp7]], [[6cad]] – hB-Raf kinase domain + pyrazole inhibitor<br /> | ||
**[[4jvg]], [[4ehg]], [[4fk3]], [[3idp]], [[4g9r]], [[4wo5]], [[4mnf]], [[4r5y]], [[4rzv]], [[4rzw]], [[4xv1]], [[4xv2]], [[4xv3]], [[4xv9]], [[4yht]], [[5c9c]], [[5hi2]], [[5ita]], [[5jrq]], [[5jsm]], [[5jt2]], [[6nsq]], [[6p7d]], [[6uuo]] – hB-Raf kinase domain (mutant) + pyrazole inhibitor<br /> | **[[4jvg]], [[4ehg]], [[4fk3]], [[3idp]], [[4g9r]], [[4wo5]], [[4mnf]], [[4r5y]], [[4rzv]], [[4rzw]], [[4xv1]], [[4xv2]], [[4xv3]], [[4xv9]], [[4yht]], [[5c9c]], [[5hi2]], [[5ita]], [[5jrq]], [[5jsm]], [[5jt2]], [[6nsq]], [[6p7d]], [[6uuo]] – hB-Raf kinase domain (mutant) + pyrazole inhibitor<br /> | ||
| - | **[[5csw]], [[5csx]], [[5ct7]], [[5fd2]], [[5hid]], [[5hie]], [[5val]], [[5vam]], [[6b8u]], [[6n0q]], [[6n0p]] - hB-Raf kinase domain + inhibitor<br /> | + | **[[5csw]], [[5csx]], [[5ct7]], [[5fd2]], [[5hid]], [[5hie]], [[5val]], [[5vam]], [[6b8u]], [[6n0q]], [[6n0p]], [[7k0v]], [[7p3b]] - hB-Raf kinase domain + inhibitor<br /> |
| + | **[[6v34]] – hB-Raf kinase domain (mutant) + inhibitor<br /> | ||
| + | **[[6xfp]], [[6xlo]] – hB-Raf kinase domain + cancer drug<br /> | ||
**[[6p3d]] – hB-Raf kinase domain (mutant) + cancer drug<br /> | **[[6p3d]] – hB-Raf kinase domain (mutant) + cancer drug<br /> | ||
**[[4mne]] – hB-Raf kinase domain + MAPKK1<br /> | **[[4mne]] – hB-Raf kinase domain + MAPKK1<br /> | ||
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**[[2ov2]] – hChk Pak-4 CRIB domain + RAC3<br /> | **[[2ov2]] – hChk Pak-4 CRIB domain + RAC3<br /> | ||
**[[2qon]], [[4fif]], [[4fih]], [[4fii]], [[4jdh]], [[4jdi]], [[4jdj]], [[4jdk]], [[6wlx]], [[6wly]] – hChk Pak-4 kinase domain + peptide<br /> | **[[2qon]], [[4fif]], [[4fih]], [[4fii]], [[4jdh]], [[4jdi]], [[4jdj]], [[4jdk]], [[6wlx]], [[6wly]] – hChk Pak-4 kinase domain + peptide<br /> | ||
| - | **[[4app]], [[4o0v]], [[4o0x]], [[4o0y]], [[4njd]], [[4xbu]], [[5bms]], [[5i0b]], [[5vee]], [[5vef]], [[5zjw]], [[5xvg]], [[5xvf]], [[5xva]] – hChk Pak-4 kinase domain + inhibitor<br /> | + | **[[4app]], [[4o0v]], [[4o0x]], [[4o0y]], [[4njd]], [[4xbu]], [[5bms]], [[5i0b]], [[5vee]], [[5vef]], [[5zjw]], [[5xvg]], [[5xvf]], [[5xva]], [[7cmb]], [[7cp3]], [[7cp4]] – hChk Pak-4 kinase domain + inhibitor<br /> |
**[[2x4z]], [[2xh5]] – hChk Pak-4 kinase domain (mutant) + inhibitor<br /> | **[[2x4z]], [[2xh5]] – hChk Pak-4 kinase domain (mutant) + inhibitor<br /> | ||
**[[5upl]], [[5upk]] – hChk Pak-4 kinase domain (mutant) + CDC42<br /> | **[[5upl]], [[5upk]] – hChk Pak-4 kinase domain (mutant) + CDC42<br /> | ||
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**[[2bzj]], [[2bzh]], [[2bzi]] – hPim1 catalytic domain (mutant) + organometallic ligand <br /> | **[[2bzj]], [[2bzh]], [[2bzi]] – hPim1 catalytic domain (mutant) + organometallic ligand <br /> | ||
**[[2oi4]], [[3bwf]] – hPim1 kinase domain (mutant) + organometallic ligand <br /> | **[[2oi4]], [[3bwf]] – hPim1 kinase domain (mutant) + organometallic ligand <br /> | ||
| - | **[[1xws]], [[4dtk]], [[4as0]], [[4alu]], [[4alv]], [[4alw]], [[4bzn]], [[4bzo]], [[6bsk]], [[5v80]], [[5v82]]. [[5toe]], [[5tex]], [[5tel]], [[5o11]], [[5o12]], [[5o13]], [[6no8]], [[6no9]], [[6kzi]], [[6l11]], [[6l12]], [[6l13]], [[6l14]], [[6l15]], [[6l16]], [[6l17]], [[6ykd]] – hPim1 kinase domain + inhibitor <br /> | + | **[[1xws]], [[4dtk]], [[4as0]], [[4alu]], [[4alv]], [[4alw]], [[4bzn]], [[4bzo]], [[6bsk]], [[5v80]], [[5v82]]. [[5toe]], [[5tex]], [[5tel]], [[5o11]], [[5o12]], [[5o13]], [[6no8]], [[6no9]], [[6kzi]], [[6l11]], [[6l12]], [[6l13]], [[6l14]], [[6l15]], [[6l16]], [[6l17]], [[6vru]], [[6ykd]] – hPim1 kinase domain + inhibitor <br /> |
**[[6ayd]] – hPim1 kinase domain (mutant)+ inhibitor <br /> | **[[6ayd]] – hPim1 kinase domain (mutant)+ inhibitor <br /> | ||
| - | **[[2o3p]], [[2o63]], [[2o64]], [[2o65]], [[3jxw]], [[3jy0]], [[3jya]], [[3r00]], [[3r01]], [[3r02]], [[3r04]], [[3vbq]], [[3vbt]], [[3vbv]], [[3vbw]], [[3vbx]], [[3vby]], [[3vc4]], [[3umx]], [[4enx]], [[4eny]], [[3umw]], [[4ll5]], [[4lm5]], [[3c4e]], [[5vuc]], [[5vub]], [[5vua]], [[4n70]], [[4n6z]], [[4n6y]], [[4mta]], [[6kzi]], [[4mbl]], [[4mbi]], [[4lmu]], [[4k1b]], [[4k18]], [[4k0y]], [[4iaa]], [[4i41]], [[6mt0]] – hPim1 catalytic domain + inhibitor <br /> | + | **[[2o3p]], [[2o63]], [[2o64]], [[2o65]], [[3jxw]], [[3jy0]], [[3jya]], [[3r00]], [[3r01]], [[3r02]], [[3r04]], [[3vbq]], [[3vbt]], [[3vbv]], [[3vbw]], [[3vbx]], [[3vby]], [[3vc4]], [[3umx]], [[4enx]], [[4eny]], [[3umw]], [[4ll5]], [[4lm5]], [[3c4e]], [[5vuc]], [[5vub]], [[5vua]], [[4n70]], [[4n6z]], [[4n6y]], [[4mta]], [[6kzi]], [[4mbl]], [[4mbi]], [[4lmu]], [[4k1b]], [[4k18]], [[4k0y]], [[4iaa]], [[4i41]], [[6mt0]], [[7oov]], [[7oow]], [[7oox]] – hPim1 catalytic domain + inhibitor <br /> |
**[[2j2i]], [[3we8]] – hPim1 catalytic domain (mutant)+ inhibitor <br /> | **[[2j2i]], [[3we8]] – hPim1 catalytic domain (mutant)+ inhibitor <br /> | ||
**[[5tur]] - hPim1 + inhibitor <br /> | **[[5tur]] - hPim1 + inhibitor <br /> | ||
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**[[4pu3]], [[4pu4]] – SoChk Hipa + Hipb + DNA - ''Shewanella oneidensis''<br /> | **[[4pu3]], [[4pu4]] – SoChk Hipa + Hipb + DNA - ''Shewanella oneidensis''<br /> | ||
**[[4pu5]] – SoChk Hipa + AMPPNP<br /> | **[[4pu5]] – SoChk Hipa + AMPPNP<br /> | ||
| + | |||
| + | *'''Chk Smg''' | ||
| + | |||
| + | **[[7pw6]] – hChk Smg1 + inhibitor – Cryo EM <br /> | ||
| + | **[[7pw9]] – hChk Smg1 + Smg9 – Cryo EM <br /> | ||
| + | **[[7pw7]] – hChk Smg1 + Smg9 + inhibitor – Cryo EM <br /> | ||
| + | **[[6l54]], [[6syt]], [[7pw4]] – hChk Smg1 + Smg8 + Smg9 – Cryo EM <br /> | ||
| + | **[[7pw5]] – hChk Smg1 + Smg8 + Smg9 + inhibitor – Cryo EM <br /> | ||
| + | **[[7pw8]] – hChk Smg1 + Smg8 + Smg9 + AMPPNP – Cryo EM <br /> | ||
| + | **[[6z3r]] – hChk Smg1 + Smg8 + Smg9 + regulator of nonsense transcripts – Cryo EM <br /> | ||
*'''Other Chk''' | *'''Other Chk''' | ||
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**[[1wak]] – hChk Sprk1 <br /> | **[[1wak]] – hChk Sprk1 <br /> | ||
**[[3dak]] – hChk Osr1 kinase domain <br /> | **[[3dak]] – hChk Osr1 kinase domain <br /> | ||
| + | **[[7okw]] – hChk Osr1 C-terminal <br /> | ||
**[[4aw2]] – hChk Mrckα kinase domain<br /> | **[[4aw2]] – hChk Mrckα kinase domain<br /> | ||
**[[6l53]] – hChk Smg1 – Cryo EM <br /> | **[[6l53]] – hChk Smg1 – Cryo EM <br /> | ||
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**[[5iri]] – mChk Sad residues 592-719<br /> | **[[5iri]] – mChk Sad residues 592-719<br /> | ||
**[[5oat]] – rfbChk – red flour beetle <br /> | **[[5oat]] – rfbChk – red flour beetle <br /> | ||
| + | **[[7t3x]] – Chk Pink1 (mutant) – louse<br /> | ||
**[[4f0g]] – smChk Roco4 kinase domain – slime mold<br /> | **[[4f0g]] – smChk Roco4 kinase domain – slime mold<br /> | ||
**[[5tos]] – AtChk Bik1 <br /> | **[[5tos]] – AtChk Bik1 <br /> | ||
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**[[2v3s]] – hChk Osr1 + hChk Wnk4 peptide <br /> | **[[2v3s]] – hChk Osr1 + hChk Wnk4 peptide <br /> | ||
**[[2vwi]] – hChk Osr1 kinase domain + ANP <br /> | **[[2vwi]] – hChk Osr1 kinase domain + ANP <br /> | ||
| - | **[[5jzj]] – hChk Dclk1 kinase domain + AMPPN <br /> | + | **[[5jzj]], ]], [[7kx6]], [[7kxw]] – hChk Dclk1 kinase domain + AMPPN <br /> |
| + | **[[7kx8]] – hChk Dclk1 C-terminal + inhibitor <br /> | ||
| + | **[[7que]], [[7quf]] – hChk Drak1 kinase domain + inhibitor<br /> | ||
**[[5jzn]] – hChk Dclk1 kinase domain + inhibitor <br /> | **[[5jzn]] – hChk Dclk1 kinase domain + inhibitor <br /> | ||
**[[4crs]] – hChk N2 kinase domain + ATPγS<br /> | **[[4crs]] – hChk N2 kinase domain + ATPγS<br /> | ||
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**[[5yh3]] – hChk Fam20C 141-578 + pseudokinase Fam20A<br /> | **[[5yh3]] – hChk Fam20C 141-578 + pseudokinase Fam20A<br /> | ||
**[[2gcd]] – rChk Tao2 kinase domain + staurosporine<br /> | **[[2gcd]] – rChk Tao2 kinase domain + staurosporine<br /> | ||
| - | **[[5yj9]] – rfbChk Pink1 kinase domain + AMPPNP<br /> | + | **[[5yj9]], [[7mp9]] – rfbChk Pink1 kinase domain + AMPPNP<br /> |
**[[6bn1]] – DmChk Hippo SARAH domain + Shar-Pei<br /> | **[[6bn1]] – DmChk Hippo SARAH domain + Shar-Pei<br /> | ||
**[[3hgk]] – Chk Pto + effector protein AVRPTOB – Currant tomato<br /> | **[[3hgk]] – Chk Pto + effector protein AVRPTOB – Currant tomato<br /> | ||
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**[[6s8f]] – yChk Tel1 + ANP – Cryo EM<br /> | **[[6s8f]] – yChk Tel1 + ANP – Cryo EM<br /> | ||
**[[5yyz]] – yChk Mek1 FHA domain + Hop1<br /> | **[[5yyz]] – yChk Mek1 FHA domain + Hop1<br /> | ||
| - | **[[5x6o]] – yChk Mec1 + LCD1 – Cryo EM<br /> | + | **[[5x6o]], [[6z3a]] – yChk Mec1 + LCD1 – Cryo EM<br /> |
| + | **[[6z2w]], [[6z2x]] – yChk Mec1 (mutant) + LCD1 – Cryo EM<br /> | ||
**[[6u6a]] – CaChk Yck2 + inhibitor<br /> | **[[6u6a]] – CaChk Yck2 + inhibitor<br /> | ||
**[[5fvm]] – Chk Tor2 + LST8 – ''Kluyveromyces maximanus''<br /> | **[[5fvm]] – Chk Tor2 + LST8 – ''Kluyveromyces maximanus''<br /> | ||
Revision as of 08:20, 8 February 2022
3D structures of serine/threonine protein kinase
Updated on 08-February-2022
