SARS-CoV-2 enzyme 3CL-PRO

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-	<SX viewer='molstar' load='' size='340' side='right' caption='' scene=''>	+	==Your Heading Here (maybe something like 'Structure')==
		+	<StructureSection load='6lu7' size='350' side='right' caption='SARS-CoV-2 NSP6 Main protease [[6lu7]])' scene=''>
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		+	Anything in this section will appear adjacent to the 3D structure and will be scrollable.
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	== Function ==		== Function ==
	'''Proteinase 3CL-PRO'''		'''Proteinase 3CL-PRO'''

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Revision as of 08:48, 8 February 2022

Your Heading Here (maybe something like 'Structure')

spinqualitylabelsall models SARS-CoV-2 NSP6 Main protease 6lu7) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Anything in this section will appear adjacent to the 3D structure and will be scrollable.

Function

Proteinase 3CL-PRO Cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. Also able to bind an ADP-ribose-1"-phosphate (ADRP).^[1][2]

Disease

Relevance

Structural highlights

See also

Coronavirus_Disease 2019 (COVID-19)

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References

1. ↑ Modeling of the SARS-COV-2 Genome
2. ↑ Zhang C, Zheng W, Huang X, Bell EW, Zhou X, Zhang Y. Protein Structure and Sequence Reanalysis of 2019-nCoV Genome Refutes Snakes as Its Intermediate Host and the Unique Similarity between Its Spike Protein Insertions and HIV-1. J Proteome Res. 2020 Apr 3;19(4):1351-1360. doi: 10.1021/acs.jproteome.0c00129., Epub 2020 Mar 24. PMID:32200634 doi:http://dx.doi.org/10.1021/acs.jproteome.0c00129