SARS-CoV-2 protein NSP11

From Proteopedia

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 <StructureSection load='' size='340' side='right' caption='Caption for this structure' scene='90/903539/Alphafold2_nsp11/1'>
 {{Theoretical_model}} {{Template:ModelConfidence}}
-To the right is an '''[[AlphaFold]]2''' 3D model of SARS CoV-2 Protein NSP11 (length = 13 amino acids, NCBI ID [https://www.ncbi.nlm.nih.gov/protein/YP_009725302.1 YP_009725302]) color coded by the pLDDT scores. It corresponds to the highest ranked model in terms of the pLDDT confidence scores, ''i.e.'', model 3<ref name="MIT_ColabFold">[https://colab.research.google.com/github/sokrypton/ColabFold/blob/main/beta/AlphaFold2_advanced.ipynb MIT ColabFold]</ref>.
+To the right is an '''[[AlphaFold]]2''' 3D model of SARS CoV-2 Protein NSP11 (length = 13 amino acids, i.e. '''SADAQSFLNGFAV''' color coded by the pLDDT scores. It corresponds to the highest ranked model in terms of the pLDDT confidence scores, ''i.e.'', model 5<ref name="MIT_ColabFold">[https://colab.research.google.com/github/sokrypton/ColabFold/blob/main/beta/AlphaFold2_advanced.ipynb MIT ColabFold]</ref>.
 == Function ==
-'''Non-structural protein 6 (nsp11)'''
+'''Non-structural protein 11 (NSP11)''' is the 13 amino acid peptide at the C-term of the large SARS-CoV-2 polyprotein ORF1ab (pp1a). It is the cleavage product of pp1a polyprotein by 3CLpro/Mpro protease at the nsp10/11 junction. Its function and whether it is actually expressed is not known.
-NSP11 is the 13 amino acid peptide at the C-term of the large polyprotein ORF1ab that SARS-CoV-2 produces. It sequence is '''SADAQSFLNGFAV'''. <ref name="MIT_ColabFold"/><ref>[https://zhanglab.ccmb.med.umich.edu/COVID-19/ Modeling of the SARS-COV-2 Genome]</ref><ref>pmid 32200634</ref>.
-== Disease ==
-== Relevance ==
 == Structural highlights ==

Revision as of 15:17, 8 February 2022

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Caption for this structure

Show:Asymmetric Unit Biological Assembly

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Theoretical Model: The protein structure described on this page was determined theoretically, and hence should be interpreted with caution.

Model Confidence:

Very high (pLDDT > 90)

Confident (90 > pLDDT > 70)

Low (70 > pLDDT > 50)

Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions below 50 pLDDT may be unstructured in isolation.

To the right is an AlphaFold2 3D model of SARS CoV-2 Protein NSP11 (length = 13 amino acids, i.e. SADAQSFLNGFAV color coded by the pLDDT scores. It corresponds to the highest ranked model in terms of the pLDDT confidence scores, i.e., model 5^[1].

Function

Non-structural protein 11 (NSP11) is the 13 amino acid peptide at the C-term of the large SARS-CoV-2 polyprotein ORF1ab (pp1a). It is the cleavage product of pp1a polyprotein by 3CLpro/Mpro protease at the nsp10/11 junction. Its function and whether it is actually expressed is not known.