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6jc4
From Proteopedia
(Difference between revisions)
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<StructureSection load='6jc4' size='340' side='right'caption='[[6jc4]], [[Resolution|resolution]] 2.30Å' scene=''> | <StructureSection load='6jc4' size='340' side='right'caption='[[6jc4]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6jc4]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JC4 OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[6jc4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_pneumoniae"_(schroeter_1886)_flugge_1886 "bacillus pneumoniae" (schroeter 1886) flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JC4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6JC4 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ureF, ureF_1, ureF_2, NCTC204_02890, NCTC5052_03968, NCTC8849_05426, NCTC9637_01222, NCTC9661_01459, SAMEA104305404_01442, SAMEA24002668_02244 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=573 "Bacillus pneumoniae" (Schroeter 1886) Flugge 1886])</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6jc4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jc4 OCA], [https://pdbe.org/6jc4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6jc4 RCSB], [https://www.ebi.ac.uk/pdbsum/6jc4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6jc4 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/A0A2X3G2L5_KLEPN A0A2X3G2L5_KLEPN]] Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.[HAMAP-Rule:MF_01385][SAAS:SAAS00101010] |
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Klebsiella pneumoniae is an opportunistic pathogen that mostly affects those with weakened immune systems. Urease is a vital enzyme that can hydrolyze urea to ammonia and carbon dioxide as a source of nitrogen for growth. Urease is also a K. pneumoniae virulence factor that enables survival of the bacterium under nutrient-limiting conditions. UreF, an important nickel-binding urease accessory protein, is involved in the insertion of Ni(2+) into the active site of urease. Here, the crystal structure of UreF from K. pneumoniae (KpUreF) is reported. Functional data show that KpUreF forms a stable dimer in solution. These results may provide a starting point for the design of urease inhibitors. | ||
| + | |||
| + | Structural characterization of the urease accessory protein UreF from Klebsiella pneumoniae.,Liu S, Wu W, Zhao Q, Liang H, Che S, Zhang H, Liu R, Zhang Q, Bartlam M Acta Crystallogr F Struct Biol Commun. 2022 Feb 1;78(Pt 2):75-80. doi:, 10.1107/S2053230X22000474. Epub 2022 Jan 31. PMID:35102896<ref>PMID:35102896</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 6jc4" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Urease accessory protein|Urease accessory protein]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 07:29, 9 February 2022
Crystal structure of the urease accessory protein UreF from Klebsiella pneumoniae
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