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7ca4
From Proteopedia
(Difference between revisions)
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| - | ==The Crystal Structure of human Bcl-2-like protein 1 from | + | ==The Crystal Structure of human Bcl-2-like protein 1 from Biortus== |
| - | <StructureSection load='7ca4' size='340' side='right'caption='[[7ca4]]' scene=''> | + | <StructureSection load='7ca4' size='340' side='right'caption='[[7ca4]], [[Resolution|resolution]] 2.70Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CA4 OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[7ca4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CA4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CA4 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BCL2L1, BCL2L, BCLX ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ca4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ca4 OCA], [https://pdbe.org/7ca4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ca4 RCSB], [https://www.ebi.ac.uk/pdbsum/7ca4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ca4 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN]] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Huang Y]] | + | [[Category: Huang, Y]] |
| - | [[Category: Lin D]] | + | [[Category: Lin, D]] |
| - | [[Category: Lv Z]] | + | [[Category: Lv, Z]] |
| - | [[Category: Wang F]] | + | [[Category: Wang, F]] |
| + | [[Category: Apoptosis]] | ||
| + | [[Category: Apoptosis regulator protein]] | ||
| + | [[Category: Bcl-2 family]] | ||
Revision as of 07:31, 9 February 2022
The Crystal Structure of human Bcl-2-like protein 1 from Biortus
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