1gc1
From Proteopedia
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'''HIV-1 GP120 CORE COMPLEXED WITH CD4 AND A NEUTRALIZING HUMAN ANTIBODY''' | '''HIV-1 GP120 CORE COMPLEXED WITH CD4 AND A NEUTRALIZING HUMAN ANTIBODY''' | ||
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[[Category: Sweet, R W.]] | [[Category: Sweet, R W.]] | ||
[[Category: Wyatt, R.]] | [[Category: Wyatt, R.]] | ||
| - | [[Category: | + | [[Category: Antigen-binding fragment of human immunoglobulin 17b]] |
| - | [[Category: | + | [[Category: Glycosylated protein]] |
| - | [[Category: | + | [[Category: Hiv-1 exterior envelope gp120]] |
| - | + | [[Category: T-cell surface glycoprotein cd4]] | |
| - | [[Category: | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:23:51 2008'' |
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 14:23, 2 May 2008
HIV-1 GP120 CORE COMPLEXED WITH CD4 AND A NEUTRALIZING HUMAN ANTIBODY
Overview
The entry of human immunodeficiency virus (HIV) into cells requires the sequential interaction of the viral exterior envelope glycoprotein, gp120, with the CD4 glycoprotein and a chemokine receptor on the cell surface. These interactions initiate a fusion of the viral and cellular membranes. Although gp120 can elicit virus-neutralizing antibodies, HIV eludes the immune system. We have solved the X-ray crystal structure at 2.5 A resolution of an HIV-1 gp120 core complexed with a two-domain fragment of human CD4 and an antigen-binding fragment of a neutralizing antibody that blocks chemokine-receptor binding. The structure reveals a cavity-laden CD4-gp120 interface, a conserved binding site for the chemokine receptor, evidence for a conformational change upon CD4 binding, the nature of a CD4-induced antibody epitope, and specific mechanisms for immune evasion. Our results provide a framework for understanding the complex biology of HIV entry into cells and should guide efforts to intervene.
About this Structure
1GC1 is a Protein complex structure of sequences from Homo sapiens and Human immunodeficiency virus 1. Full crystallographic information is available from OCA.
Reference
Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody., Kwong PD, Wyatt R, Robinson J, Sweet RW, Sodroski J, Hendrickson WA, Nature. 1998 Jun 18;393(6686):648-59. PMID:9641677 Page seeded by OCA on Fri May 2 17:23:51 2008
Categories: Homo sapiens | Human immunodeficiency virus 1 | Protein complex | Hendrickson, W A. | Kwong, P D. | Robinson, J. | Sodroski, J. | Sweet, R W. | Wyatt, R. | Antigen-binding fragment of human immunoglobulin 17b | Glycosylated protein | Hiv-1 exterior envelope gp120 | T-cell surface glycoprotein cd4
