1doa

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spinqualitylabelsall models 1doa, resolution 2.60Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

STRUCTURE OF THE RHO FAMILY GTP-BINDING PROTEIN CDC42 IN COMPLEX WITH THE MULTIFUNCTIONAL REGULATOR RHOGDI

Overview

The RhoGDI proteins serve as key multifunctional regulators of Rho family, GTP-binding proteins. The 2.6 A X-ray crystallographic structure of the, Cdc42/RhoGDI complex reveals two important sites of interaction between, GDI and Cdc42. First, the amino-terminal regulatory arm of the GDI binds, to the switch I and II domains of Cdc42 leading to the inhibition of both, GDP dissociation and GTP hydrolysis. Second, the geranylgeranyl moiety of, Cdc42 inserts into a hydrophobic pocket within the immunoglobulin-like, domain of the GDI molecule leading to membrane release. The structural, data demonstrate how GDIs serve as negative regulators of small, GTP-binding proteins and how the isoprenoid moiety is utilized in this, critical regulatory interaction.

About this Structure

1DOA is a Protein complex structure of sequences from Bos taurus and Homo sapiens with MG, GDP and GER as ligands. Full crystallographic information is available from OCA.

Reference

Structure of the Rho family GTP-binding protein Cdc42 in complex with the multifunctional regulator RhoGDI., Hoffman GR, Nassar N, Cerione RA, Cell. 2000 Feb 4;100(3):345-56. PMID:10676816

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