3dtg
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Structural analysis of mycobacterial branched chain aminotransferase- implications for inhibitor design== | ==Structural analysis of mycobacterial branched chain aminotransferase- implications for inhibitor design== | ||
| - | <StructureSection load='3dtg' size='340' side='right' caption='[[3dtg]], [[Resolution|resolution]] 1.90Å' scene=''> | + | <StructureSection load='3dtg' size='340' side='right'caption='[[3dtg]], [[Resolution|resolution]] 1.90Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3dtg]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3dtg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_smegmatis"_trevisan_1889 "bacillus smegmatis" trevisan 1889]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DTG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DTG FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=OBZ:O-BENZYLHYDROXYLAMINE'>OBZ</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=OBZ:O-BENZYLHYDROXYLAMINE'>OBZ</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3dtf|3dtf]], [[3dth|3dth]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3dtf|3dtf]], [[3dth|3dth]]</div></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ilvE, MSMEG_4276 ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ilvE, MSMEG_4276 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1772 "Bacillus smegmatis" Trevisan 1889])</td></tr> |
| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Branched-chain-amino-acid_transaminase Branched-chain-amino-acid transaminase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.42 2.6.1.42] </span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dtg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dtg OCA], [https://pdbe.org/3dtg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dtg RCSB], [https://www.ebi.ac.uk/pdbsum/3dtg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dtg ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/ILVE_MYCS2 ILVE_MYCS2]] Catalyzes the reversible transfers of an amino group from glutamate to the alpha-ketoacid of the respective amino acid in the final step in the biosynthesis of branchedchain amino acids. The amino acids can be ranked in the following order with respect to their efficiency as amino donor: Leu > Ile > Val.<ref>PMID:20445230</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 28: | Line 28: | ||
[[Category: Bacillus smegmatis trevisan 1889]] | [[Category: Bacillus smegmatis trevisan 1889]] | ||
[[Category: Branched-chain-amino-acid transaminase]] | [[Category: Branched-chain-amino-acid transaminase]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Castell, A]] | [[Category: Castell, A]] | ||
[[Category: Unge, T]] | [[Category: Unge, T]] | ||
Revision as of 08:07, 9 February 2022
Structural analysis of mycobacterial branched chain aminotransferase- implications for inhibitor design
| |||||||||||
