3e17

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==Crystal structure of the second PDZ domain from human Zona Occludens-2==
==Crystal structure of the second PDZ domain from human Zona Occludens-2==
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<StructureSection load='3e17' size='340' side='right' caption='[[3e17]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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<StructureSection load='3e17' size='340' side='right'caption='[[3e17]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3e17]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E17 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3E17 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3e17]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E17 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3E17 FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TJP2, X104, ZO2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TJP2, X104, ZO2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3e17 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e17 OCA], [http://pdbe.org/3e17 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3e17 RCSB], [http://www.ebi.ac.uk/pdbsum/3e17 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3e17 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3e17 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e17 OCA], [https://pdbe.org/3e17 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3e17 RCSB], [https://www.ebi.ac.uk/pdbsum/3e17 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3e17 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/ZO2_HUMAN ZO2_HUMAN]] Defects in TJP2 are involved in familial hypercholanemia (FHCA) [MIM:[http://omim.org/entry/607748 607748]]. FHCA is a disorder characterized by elevated serum bile acid concentrations, itching, and fat malabsorption.<ref>PMID:12704386</ref>
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[[https://www.uniprot.org/uniprot/ZO2_HUMAN ZO2_HUMAN]] Defects in TJP2 are involved in familial hypercholanemia (FHCA) [MIM:[https://omim.org/entry/607748 607748]]. FHCA is a disorder characterized by elevated serum bile acid concentrations, itching, and fat malabsorption.<ref>PMID:12704386</ref>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ZO2_HUMAN ZO2_HUMAN]] Plays a role in tight junctions and adherens junctions.
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[[https://www.uniprot.org/uniprot/ZO2_HUMAN ZO2_HUMAN]] Plays a role in tight junctions and adherens junctions.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e1/3e17_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e1/3e17_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Chen, H]]
[[Category: Chen, H]]
[[Category: Niu, L W]]
[[Category: Niu, L W]]

Revision as of 08:12, 9 February 2022

Crystal structure of the second PDZ domain from human Zona Occludens-2

PDB ID 3e17

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