SARS-CoV-2 protein ORF3a

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Revision as of 09:58, 20 April 2020 (edit) Jaime Prilusky (Talk | contribs) (New page: <SX viewer='molstar' load='' size='340' side='right' caption='' scene=''> {{Theoretical_model}} == Function == '''Open Reading Frame 3a (ORF3a)''' Forms homotetrameric potassium sensitive ...) ← Previous diff		Revision as of 10:09, 12 February 2022 (edit) (undo) Joel L. Sussman (Talk | contribs) Next diff →
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	== Function ==		== Function ==
	'''Open Reading Frame 3a (ORF3a)'''		'''Open Reading Frame 3a (ORF3a)'''
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	[[Coronavirus_Disease 2019 (COVID-19)]]		[[Coronavirus_Disease 2019 (COVID-19)]]
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	== References ==		== References ==
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Revision as of 10:09, 12 February 2022

Your Heading Here (maybe something like 'Structure')

spinqualitylabelsall models SARS-CoV-2 ORF3a (PDB entry 6xdc) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Anything in this section will appear adjacent to the 3D structure and will be scrollable.

Function

Open Reading Frame 3a (ORF3a) Forms homotetrameric potassium sensitive ion channels (viroporin) and may modulate virus release. Up-regulates expression of fibrinogen subunits FGA, FGB and FGG in host lung epithelial cells. Induces apoptosis in cell culture. Downregulates the type 1 interferon receptor by inducing serine phosphorylation within the IFN alpha-receptor subunit 1 (IFNAR1) degradation motif and increasing IFNAR1 ubiquitination.^[1][2]

Disease

Relevance

Structural highlights

See also

Coronavirus_Disease 2019 (COVID-19)

</StructureSection>

References

1. ↑ Modeling of the SARS-COV-2 Genome
2. ↑ Zhang C, Zheng W, Huang X, Bell EW, Zhou X, Zhang Y. Protein Structure and Sequence Reanalysis of 2019-nCoV Genome Refutes Snakes as Its Intermediate Host and the Unique Similarity between Its Spike Protein Insertions and HIV-1. J Proteome Res. 2020 Apr 3;19(4):1351-1360. doi: 10.1021/acs.jproteome.0c00129., Epub 2020 Mar 24. PMID:32200634 doi:http://dx.doi.org/10.1021/acs.jproteome.0c00129