SARS-CoV-2 protein NSP10
From Proteopedia
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| - | <StructureSection load='6zct' size='350' | + | <StructureSection load='6zct' size='350' side='right' caption='Crystal structure of the SARS-CoV-2 Non-structural protein 10 (PDB: [6zct]).' scene='84/842056/6zct_b-factors/2'> |
== Function == | == Function == | ||
'''Nsp10''' or '''replicase polyprotein 1ab''' plays a pivotal role in SARS-CoV viral transcription by stimulating both Nsp14 3'-5' exoribonuclease and nsp16 2'-O-methyltransferase activities and therefore plays an essential role in viral mRNAs cap methylation <ref name="zhanglab">[https://zhanglab.ccmb.med.umich.edu/COVID-19/ Modeling of the SARS-COV-2 Genome]</ref><ref name="Zhangetal2019">pmid 32200634</ref>. | '''Nsp10''' or '''replicase polyprotein 1ab''' plays a pivotal role in SARS-CoV viral transcription by stimulating both Nsp14 3'-5' exoribonuclease and nsp16 2'-O-methyltransferase activities and therefore plays an essential role in viral mRNAs cap methylation <ref name="zhanglab">[https://zhanglab.ccmb.med.umich.edu/COVID-19/ Modeling of the SARS-COV-2 Genome]</ref><ref name="Zhangetal2019">pmid 32200634</ref>. | ||
Revision as of 13:09, 14 February 2022
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References
- ↑ 1.0 1.1 Modeling of the SARS-COV-2 Genome
- ↑ 2.0 2.1 Zhang C, Zheng W, Huang X, Bell EW, Zhou X, Zhang Y. Protein Structure and Sequence Reanalysis of 2019-nCoV Genome Refutes Snakes as Its Intermediate Host and the Unique Similarity between Its Spike Protein Insertions and HIV-1. J Proteome Res. 2020 Apr 3;19(4):1351-1360. doi: 10.1021/acs.jproteome.0c00129., Epub 2020 Mar 24. PMID:32200634 doi:http://dx.doi.org/10.1021/acs.jproteome.0c00129
- ↑ Ferron F, Subissi L, Silveira De Morais AT, Le NTT, Sevajol M, Gluais L, Decroly E, Vonrhein C, Bricogne G, Canard B, Imbert I. Structural and molecular basis of mismatch correction and ribavirin excision from coronavirus RNA. Proc Natl Acad Sci U S A. 2017 Dec 26. pii: 1718806115. doi:, 10.1073/pnas.1718806115. PMID:29279395 doi:http://dx.doi.org/10.1073/pnas.1718806115
- ↑ Bouvet M, Imbert I, Subissi L, Gluais L, Canard B, Decroly E. RNA 3'-end mismatch excision by the severe acute respiratory syndrome coronavirus nonstructural protein nsp10/nsp14 exoribonuclease complex. Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):9372-7. doi:, 10.1073/pnas.1201130109. Epub 2012 May 25. PMID:22635272 doi:http://dx.doi.org/10.1073/pnas.1201130109
- ↑ Romano M, Ruggiero A, Squeglia F, Maga G, Berisio R. A Structural View of SARS-CoV-2 RNA Replication Machinery: RNA Synthesis, Proofreading and Final Capping. Cells. 2020 May 20;9(5). pii: cells9051267. doi: 10.3390/cells9051267. PMID:32443810 doi:http://dx.doi.org/10.3390/cells9051267
- ↑ 6.0 6.1 <pmid 16873246
- ↑ 7.0 7.1 <pmid 16873247
- ↑ [1]
