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2mj0

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<StructureSection load='2mj0' size='340' side='right'caption='[[2mj0]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2mj0' size='340' side='right'caption='[[2mj0]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2mj0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Monocled_cobra Monocled cobra]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MJ0 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2MJ0 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2mj0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Monocled_cobra Monocled cobra]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MJ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MJ0 FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2mj0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mj0 OCA], [http://pdbe.org/2mj0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mj0 RCSB], [http://www.ebi.ac.uk/pdbsum/2mj0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2mj0 ProSAT]</span></td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mj0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mj0 OCA], [https://pdbe.org/2mj0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mj0 RCSB], [https://www.ebi.ac.uk/pdbsum/2mj0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mj0 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TXWW_NAJKA TXWW_NAJKA]] Modulates both nicotinic and muscarinic acetylcholine receptors (nAChR and mAChR/CHRM). On nAChR, acts as an orthosteric (competitive) antagonist. On mAChR, in presence of ACh, it partially inhibits the effect of ACh (allosteric antagonist), whereas in the absence of ACh, it activates the receptor (allosteric agonist). Exerts a myorelaxant effect, induces a dose-dependent decrease in blood pressure and an increase in heart rate in mice and rats.<ref>PMID:11279130</ref> <ref>PMID:15581687</ref> <ref>PMID:17371532</ref> <ref>PMID:19682302</ref>
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[[https://www.uniprot.org/uniprot/TXWW_NAJKA TXWW_NAJKA]] Modulates both nicotinic and muscarinic acetylcholine receptors (nAChR and mAChR/CHRM). On nAChR, acts as an orthosteric (competitive) antagonist. On mAChR, in presence of ACh, it partially inhibits the effect of ACh (allosteric antagonist), whereas in the absence of ACh, it activates the receptor (allosteric agonist). Exerts a myorelaxant effect, induces a dose-dependent decrease in blood pressure and an increase in heart rate in mice and rats.<ref>PMID:11279130</ref> <ref>PMID:15581687</ref> <ref>PMID:17371532</ref> <ref>PMID:19682302</ref>
== References ==
== References ==
<references/>
<references/>

Revision as of 11:36, 16 February 2022

Spatial structure of P33A mutant of non-conventional toxin WTX from Naja kaouthia

PDB ID 2mj0

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