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3ebe
From Proteopedia
(Difference between revisions)
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==Crystal structure of xenopus laevis replication initiation factor MCM10 internal domain== | ==Crystal structure of xenopus laevis replication initiation factor MCM10 internal domain== | ||
| - | <StructureSection load='3ebe' size='340' side='right' caption='[[3ebe]], [[Resolution|resolution]] 2.30Å' scene=''> | + | <StructureSection load='3ebe' size='340' side='right'caption='[[3ebe]], [[Resolution|resolution]] 2.30Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3ebe]] is a 3 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3ebe]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/African_clawed_frog African clawed frog]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EBE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EBE FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">mcm10 ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">mcm10 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8355 African clawed frog])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ebe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ebe OCA], [https://pdbe.org/3ebe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ebe RCSB], [https://www.ebi.ac.uk/pdbsum/3ebe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ebe ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/MCM10_XENLA MCM10_XENLA]] Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication (By similarity).<ref>PMID:11864598</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: African clawed frog]] | [[Category: African clawed frog]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Eichman, B F]] | [[Category: Eichman, B F]] | ||
[[Category: Warren, E M]] | [[Category: Warren, E M]] | ||
Revision as of 11:45, 16 February 2022
Crystal structure of xenopus laevis replication initiation factor MCM10 internal domain
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