1gg4

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[[Image:1gg4.gif|left|200px]]
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{{Structure
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|PDB= 1gg4 |SIZE=350|CAPTION= <scene name='initialview01'>1gg4</scene>, resolution 2.3&Aring;
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The line below this paragraph, containing "STRUCTURE_1gg4", creates the "Structure Box" on the page.
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Deleted_entry Deleted entry], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.15 6.3.2.15] </span>
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{{STRUCTURE_1gg4| PDB=1gg4 | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1gg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gg4 OCA], [http://www.ebi.ac.uk/pdbsum/1gg4 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1gg4 RCSB]</span>
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'''CRYSTAL STRUCTURE OF ESCHERICHIA COLI UDPMURNAC-TRIPEPTIDE D-ALANYL-D-ALANINE-ADDING ENZYME (MURF) AT 2.3 ANGSTROM RESOLUTION'''
'''CRYSTAL STRUCTURE OF ESCHERICHIA COLI UDPMURNAC-TRIPEPTIDE D-ALANYL-D-ALANINE-ADDING ENZYME (MURF) AT 2.3 ANGSTROM RESOLUTION'''
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[[Category: Munshi, S.]]
[[Category: Munshi, S.]]
[[Category: Yan, Y.]]
[[Category: Yan, Y.]]
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[[Category: alpha/beta sheet]]
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[[Category: Alpha/beta sheet]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:31:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:43:20 2008''
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Revision as of 14:31, 2 May 2008

Image:1gg4.gif

Template:STRUCTURE 1gg4

CRYSTAL STRUCTURE OF ESCHERICHIA COLI UDPMURNAC-TRIPEPTIDE D-ALANYL-D-ALANINE-ADDING ENZYME (MURF) AT 2.3 ANGSTROM RESOLUTION


Overview

MurF is required to catalyze the final step in the synthesis of the cytoplasmic precursor of the bacterial cell wall peptidoglycan, rendering it an attractive target for antibacterial drug development. The crystal structure of the MurF apo-enzyme has been determined using the multiwavelength anomalous dispersion method and refined to 2.3 A resolution. It contains three consecutive open alpha/beta-sheet domains. In comparison with the complex crystal structures of MurD and its substrates, The topology of the N-terminal domain of MurF is unique, while its central and C-terminal domains exhibit similar mononucleotide and dinucleotide-binding folds, respectively. The apo-enzyme of MurF crystal structure reveals an open conformation with the three domains juxtaposed in a crescent-like arrangement creating a wide-open space where substrates are expected to bind. As such, catalysis is not feasible and significant domain closure is expected upon substrate binding.

About this Structure

1GG4 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of Escherichia coli UDPMurNAc-tripeptide d-alanyl-d-alanine-adding enzyme (MurF) at 2.3 A resolution., Yan Y, Munshi S, Leiting B, Anderson MS, Chrzas J, Chen Z, J Mol Biol. 2000 Dec 1;304(3):435-45. PMID:11090285 Page seeded by OCA on Fri May 2 17:31:16 2008

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