1nsh

From Proteopedia

(Difference between revisions)

Revision as of 08:23, 23 February 2022

Solution Structure of Rabbit apo-S100A11 (19 models)

Structural highlights

1nsh is a 2 chain structure with sequence from European rabbit. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Gene:	S100A11 OR S100C OR PCALG (European rabbit)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[S10AB_RABIT] Facilitates the differentiation and the cornification of keratinocytes (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

S100A11 is a homodimeric EF-hand calcium binding protein that undergoes a calcium-induced conformational change and interacts with the phospholipid binding protein annexin I to coordinate membrane association. In this work, the solution structure of apo-S100A11 has been determined by NMR spectroscopy to uncover the details of its calcium-induced structural change. Apo-S100A11 forms a tight globular structure having a near antiparallel orientation of helices III and IV in calcium binding site II. Further, helices I and IV, and I and I', form a more closed arrangement than observed in other apo-S100 proteins. This helix arrangement in apo-S100A11 partially buries residues in helices I (P3, E11, A15), III (V55, R58, M59), and IV (A86, C87, S90) and the linker (A45, F46), which are required for interaction with annexin I in the calcium-bound state. In apo-S100A11, this results in a "masked" binding surface that prevents annexin I binding but is uncovered upon calcium binding.

Unmasking the annexin I interaction from the structure of Apo-S100A11.,Dempsey AC, Walsh MP, Shaw GS Structure. 2003 Jul;11(7):887-97. PMID:12842051^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Dempsey AC, Walsh MP, Shaw GS. Unmasking the annexin I interaction from the structure of Apo-S100A11. Structure. 2003 Jul;11(7):887-97. PMID:12842051

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1nsh"

@@ Line 3: / Line 3: @@
 <StructureSection load='1nsh' size='340' side='right'caption='[[1nsh]], [[NMR_Ensembles_of_Models | 19 NMR models]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1nsh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/European_rabbit European rabbit]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NSH OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1NSH FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1nsh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/European_rabbit European rabbit]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NSH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NSH FirstGlance]. <br>
-</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">S100A11 OR S100C OR PCALG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9986 European rabbit])</td></tr>
+</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">S100A11 OR S100C OR PCALG ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9986 European rabbit])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1nsh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nsh OCA], [http://pdbe.org/1nsh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1nsh RCSB], [http://www.ebi.ac.uk/pdbsum/1nsh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1nsh ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nsh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nsh OCA], [https://pdbe.org/1nsh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nsh RCSB], [https://www.ebi.ac.uk/pdbsum/1nsh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nsh ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/S10AB_RABIT S10AB_RABIT]] Facilitates the differentiation and the cornification of keratinocytes (By similarity).
+[[https://www.uniprot.org/uniprot/S10AB_RABIT S10AB_RABIT]] Facilitates the differentiation and the cornification of keratinocytes (By similarity).
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]

1nsh

From Proteopedia

Revision as of 08:23, 23 February 2022

Solution Structure of Rabbit apo-S100A11 (19 models)

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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