1ggl
From Proteopedia
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'''HUMAN CELLULAR RETINOL BINDING PROTEIN III''' | '''HUMAN CELLULAR RETINOL BINDING PROTEIN III''' | ||
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[[Category: Stoppini, M.]] | [[Category: Stoppini, M.]] | ||
[[Category: Zanotti, G.]] | [[Category: Zanotti, G.]] | ||
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| - | [[Category: | + | [[Category: Retinol binding protein]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 17:32:08 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 14:32, 2 May 2008
HUMAN CELLULAR RETINOL BINDING PROTEIN III
Overview
Two cellular retinol-binding proteins (CRBP I and II) with distinct tissue distributions and retinoid-binding properties have been recognized thus far in mammals. Here, we report the identification of a human retinol-binding protein resembling type I (55.6% identity) and type II (49.6% identity) CRBPs, but with a unique H residue in the retinoid-binding site and a distinctively different tissue distribution. Additionally, this binding protein (CRBP III) exhibits a remarkable sequence identity (62.2%) with the recently identified iota-crystallin/CRBP of the diurnal gecko Lygodactylus picturatus [Werten, P. J. L., Roll, B., van Alten, D. M. F. & de Jong, W. W. (2000) Proc. Natl. Acad. Sci. USA 97, 3282-3287 (First Published March 21, 2000; 10.1073/pnas.050500597)]. CRBP III and all-trans-retinol form a complex (K(d) approximately 60 nM), the absorption spectrum of which is characterized by the peculiar fine structure typical of the spectra of holo-CRBP I and II. As revealed by a 2.3-A x-ray molecular model of apo-CRBP III, the amino acid residues that line the retinol-binding site in CRBP I and II are positioned nearly identically in the structure of CRBP III. At variance with the human CRBP I and II mRNAs, which are most abundant in ovary and intestine, respectively, the CRBP III mRNA is expressed at the highest levels in kidney and liver thus suggesting a prominent role for human CRBP III as an intracellular mediator of retinol metabolism in these tissues.
About this Structure
1GGL is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Identification, retinoid binding, and x-ray analysis of a human retinol-binding protein., Folli C, Calderone V, Ottonello S, Bolchi A, Zanotti G, Stoppini M, Berni R, Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):3710-5. PMID:11274389 Page seeded by OCA on Fri May 2 17:32:08 2008
