7s8t
From Proteopedia
(Difference between revisions)
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==M. xanthus ferritin-like protein EncC== | ==M. xanthus ferritin-like protein EncC== | ||
| - | <StructureSection load='7s8t' size='340' side='right'caption='[[7s8t]]' scene=''> | + | <StructureSection load='7s8t' size='340' side='right'caption='[[7s8t]], [[Resolution|resolution]] 2.49Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7S8T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7S8T FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7s8t]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7S8T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7S8T FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7s8t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7s8t OCA], [https://pdbe.org/7s8t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7s8t RCSB], [https://www.ebi.ac.uk/pdbsum/7s8t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7s8t ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7s8t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7s8t OCA], [https://pdbe.org/7s8t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7s8t RCSB], [https://www.ebi.ac.uk/pdbsum/7s8t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7s8t ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Encapsulins are bacterial organelle-like cages involved in various aspects of metabolism, especially protection from oxidative stress. They can serve as vehicles for a wide range of medical applications. Encapsulin shell proteins are structurally similar to HK97 bacteriophage capsid protein and their function depends on the encapsulated cargos. The Myxococcus xanthus encapsulin system comprises EncA and three cargos: EncB, EncC, and EncD. EncB and EncC are similar to bacterial ferritins that can oxidize Fe(+2) to less toxic Fe(+3). We analyzed EncA, EncB, and EncC by cryo-EM and X-ray crystallography. Cryo-EM shows that EncA cages can have T = 3 and T = 1 symmetry and that EncA T = 1 has a unique protomer arrangement. Also, we define EncB and EncC binding sites on EncA. X-ray crystallography of EncB and EncC reveals conformational changes at the ferroxidase center and additional metal binding sites, suggesting a mechanism for Fe oxidation and storage within the encapsulin shell. | ||
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| + | Structural characterization of the Myxococcusxanthus encapsulin and ferritin-like cargo system gives insight into its iron storage mechanism.,Eren E, Wang B, Winkler DC, Watts NR, Steven AC, Wingfield PT Structure. 2022 Feb 2. pii: S0969-2126(22)00008-9. doi:, 10.1016/j.str.2022.01.008. PMID:35150605<ref>PMID:35150605</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7s8t" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Eren E]] | + | [[Category: Eren, E]] |
| + | [[Category: Cargo protein]] | ||
| + | [[Category: Cytosolic protein]] | ||
| + | [[Category: Encapsulated ferritin]] | ||
| + | [[Category: Encapsulin]] | ||
| + | [[Category: Ferroxidase]] | ||
Revision as of 08:45, 23 February 2022
M. xanthus ferritin-like protein EncC
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